Obstructive Lung Diseases |

The Vitamin D Receptors May Function as Antiinflammatory Effects in Patients With COPD FREE TO VIEW

Masaki Ishii, PhD; Yasuhiro Yamaguchi, PhD; Tomomi Nakamura; Masahiro Akishita, PhD
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University of Tokyo, Bunkyo-ku, Japan

Chest. 2015;148(4_MeetingAbstracts):690A. doi:10.1378/chest.2249480
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: Vitamin D insufficiency is increasingly being recognized as a prevalent problem in the general population, especially in patients with chronic lung diseases. It is speculated that the development of COPD causes a decreased level of vitamin D, which worsens the severity of COPD. The activity of vitamin D homeostasis may be one of important candidate factors which determine the severity of COPD in cigarette smokers. Several studies indicated that vitamin D had a range of anti-inflammatory functions associated with the balance of Th1/Th2. Cigarette smoke is the most established risk for COPD, however, its effects on the progression of VDR are still unclear. In this study we investigated the role of VDR as anti-inflammatory effects in alveolar epithelial cells exposed to cigarette smoke.

METHODS: To investigate the role of VDR in cigarette smoke-induced lung inflammation, we first examined the mRNA level under the condition of CSE and then measured the induction of inflammatory cytokines by CSE in A549 cells. To investigate the relationships between level of VDR and inflammation, A549 cells were transfected with siRNA for VDR and the mRNA levels of inflammatory cytokines were measured compared with control siRNA.

RESULTS: The mRNA level of VDR was decreased under the condition of CSE. The mRNA levels of inflammatory cytokines (MIP-1a, IP-10 and MMP-12) were increased under the condition of CSE accompanied with the decreased level of VDR. Furthermore, the mRNA levels of these inflammatory cytokines were increased under the condition the condition of decreased level of VDR induced by siRNA for VDR.

CONCLUSIONS: Cigarette smoke suppressed the expression of VDR in alveolar epithelial cells. The decreased level of VDR caused was negatively correlated with the increase of inflammatory cytokines. Inflammatory cytokines were induced by not only cigarette smoke but also the reduction of VDR caused by cigarette smoke.

CLINICAL IMPLICATIONS: These results have therapeutic implications in the progression of COPD. Thus, it is speculated that to clarify the roles of vitamin D or vitamin D receptors in lungs will lead to the medication associated with anti-inflammatory roles for COPD.

DISCLOSURE: The following authors have nothing to disclose: Masaki Ishii, Yasuhiro Yamaguchi, Tomomi Nakamura, Masahiro Akishita

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