SESSION TITLE: Asthma Outcomes
SESSION TYPE: Original Investigation Slide
PRESENTED ON: Sunday, October 25, 2015 at 07:30 AM - 08:30 AM
PURPOSE: Was to evaluate the impact of COPD and asthma on cognitive status using Montreal cognitive assessment (MoCA) questionnaire and auditory event related potential, P300 test.
METHODS: We enrolled 40 patients with COPD, 40 patients with asthma and 20 healthy subjects (control group). We analyzed the differences in MoCA score and P300 latency between these three groups and also the correlation between these scores and patient characteristics
RESULTS: We observed significantly prolonged P300 latency (P < 0.04) and reduced MoCA scores in COPD group compared to asthma group (P < 0.002). 34/40 COPD patients had prolongation of P300 latency and reduced MoCA scores. However, 20/40 asthma patients had prolongation of P300 latency and 24/40 asthma patients had reduced MoCA scores. P300 latency correlated significantly with age (r = 0.423, P < 0.007), duration of disease(r =0.622, P < 0.0001) PaO2 (r =−0.490, P < 0.001), SaO2 (r =−0.496, P < 0.003) and FEV1/FVC (r =−0.353, P < 0.026) in COPD group. MoCA score was significantly correlated with WBC (r = 0.45) in COPD group and with BMI (r = 0.236, P < 0.05) in asthma group. We did not observe any statistically significant correlation between P300 abnormalities and patients’ characteristics in asthma group (P > 0.05 for all).
CONCLUSIONS: COPD significantly decreases the cognitive status compared to bronchial asthma. MoCA abnormalities were comparable to P300 abnormalities in COPD and asthma patients
CLINICAL IMPLICATIONS: This study shows for the first time that COPD significantly decreases the cognitive status compared to bronchial asthma. Longer latency of P300 appears to be an expected sequel of COPD. MoCA abnormalities were comparable to P300 abnormalities in COPD and asthma patients
DISCLOSURE: The following authors have nothing to disclose: Abdellah Ali, Amir Mohamed
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