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Pulmonary Procedures |

Assessment of Mineral Fibers and Particles in BALF in Patients With Interstitial Lung Diseases Using Electron Microscopy

Takashi Kido, MD; Yasuo Morimoto, MD; Hiroshi Ishimoto, MD; Takaaki Ogoshi, MD; Chinatsu Nishida, MD; Kei Yamasaki, MD; Toshinori Kawanami, MD; Yukiko Kawanami, MD; Kazuhiro Yatera, MD; Hiroshi Mukae, MD
Author and Funding Information

University of Occupational and Environmental Health, Japan, Kitakyushu, Japan


Chest. 2015;148(4_MeetingAbstracts):826A. doi:10.1378/chest.2232141
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Abstract

SESSION TITLE: Interventional Pulmonology Posters II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: To investigate the utility of electron microscopic analysis using bronchoalveolar lavage fluid (BALF) for the diagnosis of interstitial lung diseases.

METHODS: A total of 107 patients with interstitial lung diseases were divided into two groups, positive and negative for the history of occupational exposure of mineral particles and fibers (the positive history group and the negative history group). We compared the results of analyses of mineral fibers and particles including asbestos fibers in BALF with scanning X-ray analytical electron microscopy in these two groups.

RESULTS: There were 48 patients in the positive history group and 59 patients in the negative history group. Asbestos fibers were detected in 11 patients in the positive history group, and there were no patients with asbestos detection in BALF in the negative history group. In patients in whom asbestos fibers were detected, light microscopic examination only revealed asbestos bodies in 4 out of these 11 patients. Higher fraction of particles including Fe and P were observed in the positive history group compared with the negative history group.

CONCLUSIONS: Electron microscopic analysis is useful for detecting asbestos fibers. In addition, detecting Fe and P using electron microscope may also be useful for the diagnosis of occupational lung diseases. These results suggest that assessment of mineral fibers and particles in BALF using electron microscopy is useful for the diagnosis of occupational interstitial lung diseases.

CLINICAL IMPLICATIONS: Inhalation of mineral fibers and particles increases the risk of developing occupational interstitial lung diseases. Analysis of BALF is useful for the diagnosis of diffuse lung diseases. However, the diagnostic value of an assessment of mineral fibers and particles in BALF with electron microscopy for the diagnosis of occupational interstitial lung diseases is unclear. Our results show the usefulness of electron microscope using BALF for the diagnosis of occupational interstitial lung diseases.

DISCLOSURE: The following authors have nothing to disclose: Takashi Kido, Yasuo Morimoto, Hiroshi Ishimoto, Takaaki Ogoshi, Chinatsu Nishida, Kei Yamasaki, Toshinori Kawanami, Yukiko Kawanami, Kazuhiro Yatera, Hiroshi Mukae

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