0
Obstructive Lung Diseases |

Oscillometric Bronchodilator Response in 3-5 Years Old Healthy and Asthmatic Filipino Children

Gemmalyn Esguerra, MD; Emily Resurreccion, MD; Kristine Elisa Kionisala, MD; Jenni Rose Dela Cruz, MD
Author and Funding Information

Philippine Children's Medical Center, Magalang, Philippines


Chest. 2015;148(4_MeetingAbstracts):669A. doi:10.1378/chest.2226425
Text Size: A A A
Published online

Abstract

SESSION TITLE: Asthma - Bronchiectasis Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM

PURPOSE: To compare the change in oscillometric parameters after inhalation of a beta-2-agonist among healthy and asthmatic children aged 3 to 5 years old using impulse oscillometry.

METHODS: Respiratory impedance at baseline and after 15 minutes of one dose of Salbutamol nebulization was measured with the impulse oscillometry(IOS) using the VIASYS (Healthcare,Leibnizstr. Hoechberg Germany)at resistance at 5Hz and 20 HZ and reactance at 5HZ in 310 children aged 3-5years old. For the calculation of threshold or cutoff values, receiver operating characteristic (ROC) curves were drawn and was determined by the Youden index. Partial correlation study was done among multiple parameters to determine best positive correlation for diagnosis of asthma.

RESULTS: Fifty-six (18.1%) asthmatic subjects and 254 (81.9%) healthy subjects were able to complete the study. Mean percent (standard error of the mean) baseline pre bronchodilator indices for asthma were 1.21 ± 0.02 kPa/L/s for Z5Hz; 1.15 ± 0.02 kPa/L/s for R5Hz; 0.83 ± 0.01 kPa/L/s for R20Hz and -0.37 ± 0.01 kPa/L/s for X5Hz. In normal healthy subjects, the baseline mean values were 1.09 ± 0.01 kPa/L/s for Z5Hz; 1.04 ± 0.01 kPa/L/s for R5Hz; 0.79 ± 0.01 kPa/L/s for R20 Hz and -0.31 ± 0.01 kPa/L/s for X5Hz. Mean percent change initial values of asthmatics were -29.03% ± 0.73 for Z5Hz; -28.77% ± 0.81 for R5Hz; -22.96 % ± 0.97 for R20 Hz and 36.91 % ± 1.62 for X5Hz. Cut off values for bronchodilator response in diagnosing asthma using the percent change initial were as follows: -19.98% for Z5Hz with sensitivity of 100% and specificity of 96%; -21.25% for R5Hz with sensitivity of 95% and specificity of 98%; -13.96 % for R20 Hz with sensitivity of 93% and specificity of 78% and -24.25 % for X5Hz with sensitivity of 88% and specificity of 88%., Percent initial change of Z5Hz and R5Hz (r = 0.938, p<0.001), Z5Hz and R20Hz (r = 0.455, p<0.001), R5Hz and R20Hz (r = 0.488, p<0.001), Z5Hz and X5Hz (r = 0.146, p=0.010) are significantly correlated.

CONCLUSIONS: Post-bronchodilator change of -20% in Z5Hz and -21% in R5Hz from the initial has strong positive correlation for the diagnosis of asthma. The computed percent change post-bronchodilator for Z5Hz and R5Hz are the best parameters showing better accuracy in specificity and sensitivity in the diagnosis of asthma in our population.

CLINICAL IMPLICATIONS: This study does not aim to replace spirometry as standard of care for diagnosis of asthma, but oscillometry can be an objective option for these children that cannot perform spirometry.

DISCLOSURE: The following authors have nothing to disclose: Gemmalyn Esguerra, Emily Resurreccion, Kristine Elisa Kionisala, Jenni Rose Dela Cruz

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Muscarinic Receptor Antagonists. Handb Exp Pharmacol Published online Oct 28, 2016;
Leukotriene Receptor Antagonists and Antiallergy Drugs. Handb Exp Pharmacol Published online Nov 09, 2016;
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543