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Original Research: Critical Care |

Clinical Characteristics and Outcomes Are Similar in ARDS Diagnosed by Oxygen Saturation/Fio2 Ratio Compared With Pao2/Fio2 RatioSpo2/Fio2 Ratio for ARDS

Wei Chen, MD; David R. Janz, MD, MSCI; Ciara M. Shaver, MD, PhD; Gordon R. Bernard, MD; Julie A. Bastarache, MD; Lorraine B. Ware, MD
Author and Funding Information

From the Division of Allergy, Pulmonary, and Critical Care Medicine (Drs Chen, Shaver, Bernard, Bastarache, and Ware), Vanderbilt University School of Medicine, Nashville, TN; the Division of Pulmonary and Critical Care Medicine (Dr Chen), Chiayi Christian Hospital, Chiayi, Taiwan; the Department of Life Science (Dr Chen), National Chung Hsing University, Taichung, Taiwan; the College of Nursing (Dr Chen), Da-Yeh University, Taichung, Taiwan; and the Section of Pulmonary and Critical Care Medicine (Dr Janz), Louisiana State University School of Medicine, New Orleans, LA.

CORRESPONDENCE TO: Wei Chen, MD, Division of Pulmonary and Critical Care Medicine, Chia-Yi Christian Hospital, 539 Jhongsiao Rd, Chia-Yi 600, Taiwan, China; e-mail: peteralfa2004@yahoo.com.tw


FUNDING/SUPPORT: This study was funded by the National Institutes of Health [Grants NIH HL103836, HL112656-02, T32 HL087738, and UL1 RR024975], an American Heart Association Clinical Research Award, and an American Heart Association Established Investigator Award.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;148(6):1477-1483. doi:10.1378/chest.15-0169
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BACKGROUND:  Oxygen saturation as measured by pulse oximetry/Fio2 (SF) ratio is highly correlated with the Pao2/Fio2 (PF) ratio in patients with ARDS. However, it remains uncertain whether SF ratio can be substituted for PF ratio for diagnosis of ARDS and whether SF ratio might identify patients who are systemically different from patients diagnosed by PF ratio.

METHODS:  We conducted a secondary analysis of a large observational prospective cohort study. Patients were eligible if they were admitted to the medical ICU and fulfilled the Berlin definition of ARDS with hypoxemia criteria using either the standard PF threshold (PF ratio ≤ 300) or a previously published SF threshold (SF ratio ≤ 315).

RESULTS:  Of 362 patients with ARDS, 238 (66%) received a diagnosis by PF ratio and 124 (34%) by SF ratio. In a small group of patients who received diagnoses of ARDS by SF ratio who had arterial blood gas measurements on the same day (n = 10), the PF ratio did not meet ARDS criteria. There were no major differences in clinical characteristics or comorbidities between groups with the exception of APACHE (Acute Physiology and Chronic Health Evaluation) II scores, which were higher in the group diagnosed by PF ratio. However, this difference was no longer apparent when arterial blood gas-dependent variables (pH, Pao2) were removed from the APACHE II score. There were also no differences in clinical outcomes including duration of mechanical ventilation (mean, 7 days in both groups; P = .25), duration of ICU stay (mean, 10 days vs 9 days in PF ratio vs SF ratio; P = .26), or hospital mortality (36% in both groups, P = .9).

CONCLUSIONS:  Patients with ARDS diagnosed by SF ratio have very similar clinical characteristics and outcomes compared with patients diagnosed by PF ratio. These findings suggest that SF ratio could be considered as a diagnostic tool for early enrollment into clinical trials.

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