In the high-level containment units in the European Union and United States, where climate factors are less restrictive, robust staffing needs remain a significant although not insurmountable challenge. Other challenges in the provision of critical care to patients with EVD include lack of availability of specialized imaging studies, including CT scan and MRI, and limited access to microbiologic or other specialized non-point-of-care laboratory testing. We agree, based on our own experience as well as that described by others in US and European Union centers, that caring for patients with EVD presents multiple logistic and human challenges.1 The decision to provide continuous intensivist coverage for critically ill patients with EVD must be addressed in the context of available resources, human and otherwise, at any given facility. The geographic location and environmental conditions in a treatment facility are among the many factors that must be taken into account when deciding what level of care is feasible and safe. Lessons learned from this epidemic should guide ongoing activities for present and future outbreaks to maximize the level of quality care delivered to patients with EVD.