We prospectively collected a database from patients with pleural effusions. More than 500 patients with pleural effusions were included. As is expected from a comprehensive cancer center, the majority of patients suffered from malignant pleural effusion. After excluding nonmalignant effusions, 381 patients were enrolled for this analysis. In this cohort, the majority of patients were women (232 of 381). Median age of patients was 61 years. Pleural effusion was predominantly right-sided (213 of 381). In contrast to the population described by Fysh and colleagues,1 our database consisted of more patients suffering from breast cancer (103 of 381), as previously reported.3 At the time of analysis, 42 patients were still alive without either pleurodesis or indwelling pleural catheter insertion, 170 patients (45%) underwent definitive treatment of recurrent malignant pleural effusion, and 169 patients died without a definitive treatment of pleural effusion. No data were available on recurrent thoracenteses.