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A 43-Year-Old Man With Antisynthetase Syndrome Presenting With Acute Worsening of Dyspnea43-Year-Old Man With Antisynthetase Syndrome

Hrishikesh S. Kulkarni, MD; Fernando R. Gutierrez, MD; Vladimir Despotovic, MD; Tonya D. Russell, MD
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From the Division of Pulmonary and Critical Care (Drs Kulkarni, Despotovic, and Russell), and the Division of Rheumatology (Dr Despotovic), Department of Medicine, Washington University in St. Louis; and the Cardiothoracic Imaging Section (Dr Gutierrez), Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO.

CORRESPONDENCE TO: Hrishikesh S. Kulkarni, MD, Division of Pulmonary and Critical Care, Washington University in St. Louis, 660 S Euclid Ave, Campus Box 8052, St. Louis, MO 63110; e-mail: hkulkarn@dom.wustl.edu


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;147(6):e215-e219. doi:10.1378/chest.14-2402
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A 43-year-old man with antisynthetase syndrome was seen in our pulmonary clinic for worsening dyspnea. He was recently diagnosed with antisynthetase syndrome because he had nonspecific interstitial pneumonitis on a surgical lung biopsy and polymyositis associated with anti-Jo-1 and anti-SSA-52 autoantibodies. Along with his worsening dyspnea, he also had a dry cough, lower extremity edema, and abdominal distension. He had gained 11 kg over 1 month. He had been taking prednisone 40 mg daily 2 months prior, which had been recently weaned to 20 mg daily. He had also been on mycophenolate mofetil but had recently discontinued it on his own.

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