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Running Short on TimeTransplant for Telomere-Related Pulmonary Fibrosis: Lung Transplant Evaluation for Telomere-Related Pulmonary Fibrosis

Christine Kim Garcia, MD, PhD
Author and Funding Information

From the McDermott Center for Human Growth and Development and the Department of Internal Medicine, University of Texas Southwestern Medical Center.

CORRESPONDENCE TO: Christine Kim Garcia, MD, PhD, University of Texas Southwestern Medical Center, McDermott Center for Human Growth and Development and the Department of Internal Medicine, 5323 Harry Hines Blvd, Dallas, TX 75390-8591; e-mail: christine.garcia@utsouthwestern.edu


FINANCIAL/NONFINANCIAL DISCLOSURES: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;147(6):1450-1452. doi:10.1378/chest.15-0077
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Extract

Idiopathic pulmonary fibrosis (IPF) is the most common subtype of interstitial lung disease (ILD) and disproportionately affects older adults.1 The pathogenesis of IPF in some patients has been linked to shortening of chromosomal ends, or telomeres, which is regulated by both genetic and environmental factors.2,3 Since telomeres erode with each cycle of cell replication, this genomic timepiece provides a surrogate measure of molecular age and, thus, provides a biologic explanation for the increased incidence of IPF in older patients.

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