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Ventilator-Associated PneumoniaVentilator-Associated Pneumonia Diagnostics: The Role of Emerging Therapies and Diagnostics

Marin H. Kollef, MD, FCCP
Author and Funding Information

From the Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine.

CORRESPONDENCE TO: Marin H. Kollef, MD, FCCP, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8052, St. Louis, MO 63110; e-mail: mkollef@dom.wustl.edu


FUNDING/SUPPORT: Dr Kollef is supported in part by the Barnes-Jewish Hospital Foundation.

FINANCIAL/NONFINANCIAL DISCLOSURES: The author has reported to CHEST the following conflicts of interest: Dr Kollef has served as a consultant for Cubist Pharmaceuticals Inc, Merck & Co Inc, Forest Laboratories Inc, Accelerate Diagnostics Inc, Cardeas Pharma Corp, Theravance Biopharma Inc, Sanofi Pasteur SA, Basilea Pharmaceutica Ltd, Medimmune LLC, AstraZeneca plc, bioMérieux Inc, and the Academy for Infection Management.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;147(6):1448-1450. doi:10.1378/chest.14-2745
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Extract

Ventilator-associated pneumonia (VAP) is one of the most common infections in patients who are mechanically ventilated and is frequently due to infection by antibiotic-resistant bacteria. Mortality, hospital lengths of stay, and health-care costs are typically greater among patients with respiratory failure complicated by VAP compared with patients who do not develop VAP.1 Moreover, we know that the administration of inappropriate initial antibiotic therapy for VAP, usually due to the presence of multidrug-resistant bacteria as the causative pathogens, is associated with greater hospital mortality and longer hospital lengths of stay.2

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