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Original Research: Critical Care |

Critical Care Ultrasonography Differentiates ARDS, Pulmonary Edema, and Other Causes in the Early Course of Acute Hypoxemic Respiratory FailureFocused Cardiac and Thoracic Ultrasonography

Hiroshi Sekiguchi, MD; Louis A. Schenck, MS; Ryohei Horie, MD; Jun Suzuki, MD; Edwin H. Lee, MD; Brendan P. McMenomy, MD; Tien-En Chen, MD; Alexander Lekah, MD; Sunil V. Mankad, MD, FCCP; Ognjen Gajic, MD, FCCP
Author and Funding Information

From the Division of Pulmonary and Critical Care Medicine (Drs Sekiguchi, Horie, Suzuki, Lee, and Gajic), Division of Biomedical Statistics and Informatics (Mr Schenck), Department of Radiology (Drs McMenomy and Lekah), Division of Cardiovascular Diseases (Drs Chen and Mankad), and Division of Health Care Policy and Research (Dr Gajic), Mayo Clinic, Rochester, MN.

CORRESPONDENCE TO: Hiroshi Sekiguchi, MD, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: sekiguchi.hiroshi@mayo.edu


FUNDING/SUPPORT: This work was supported by a Mayo Clinic Department of Medicine Write-up and Publish (WRAP) grant.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;148(4):912-918. doi:10.1378/chest.15-0341
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BACKGROUND:  Pathogenic causes of acute hypoxemic respiratory failure (AHRF) can be difficult to identify at early clinical presentation. We evaluated the diagnostic utility of combined cardiac and thoracic critical care ultrasonography (CCUS).

METHODS:  Adult patients in the ICU were prospectively enrolled from January through September 2010 with a Pao2/Fio2 ratio < 300 on arterial blood gas (ABG) analysis within 6 h of a new hypoxemic event or the ICU admission. Focused cardiac and thoracic CCUS was conducted within 6 h of ABG testing. Causes of AHRF were categorized into cardiogenic pulmonary edema (CPE), ARDS, and miscellaneous causes after reviewing the hospitalization course in electronic medical records.

RESULTS:  One hundred thirty-four patients were enrolled (median Pao2/Fio2 ratio, 191; interquartile range, 122-253). Fifty-nine patients (44%) received a diagnosis of CPE; 42 (31%), ARDS; and 33 (25%), miscellaneous cause. Analysis of CCUS findings showed that a low B-line ratio (proportion of chest zones with positive B-lines relative to all zones examined) was predictive of miscellaneous cause vs CPE or ARDS (receiver operating characteristic area under the curve [AUC], 0.82; 95% CI, 0.75-0.88). For further differentiation of CPE from ARDS, left-sided pleural effusion (> 20 mm), moderately or severely decreased left ventricular function, and a large inferior vena cava minimal diameter (> 23 mm) were predictive of CPE (AUC, 0.79; 95% CI, 0.70-0.87).

CONCLUSIONS:  Combined cardiac and thoracic CCUS assists in early bedside differential diagnosis of ARDS, CPE, and other causes of AHRF.

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