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Original Research: Chest Infections |

Risk Factors for TB in Patients With Early Gastric CancerGastrectomy as a Risk Factor for TB: Is Gastrectomy a Significant Risk Factor for TB?

Il Ju Choi, MD, PhD; Young-Woo Kim, MD, PhD; Hee Seok Lee, MD; Keun Won Ryu, MD, PhD; Hong Man Yoon, MD; Bang Wool Eom, MD; Chan Gyoo Kim, MD, PhD; Jong Yeul Lee, MD; Soo-Jeong Cho, MD, PhD; Byung-Ho Nam, PhD
Author and Funding Information

From the Center for Gastric Cancer (Drs Choi, Y.-W. Kim, Ryu, Yoon, Eom, C. G. Kim, J. Y. Lee, and Cho), the Respiratory Clinic and Division of Respiratory and Critical Care Medicine (Dr H. S. Lee), Department of Internal Medicine, and the Cancer Biostatistics Branch (Dr Nam), Research Institute for National Cancer Control and Evaluation, National Cancer Center, Goyang, Korea.

CORRESPONDENCE TO: Hee Seok Lee, MD, Respiratory Clinic and Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si Gyeonggi-do, 410-769, South Korea; e-mail: jekyde7@gmail.com


Drs Choi and Y.-W. Kim are co-first authors.

FUNDING/SUPPORT: This work was supported by the National Cancer Center [Grant 1210551].

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;148(3):774-783. doi:10.1378/chest.15-0056
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BACKGROUND:  Gastrectomy is known as one of the risk factors for TB. However, there is no study about the association between TB development and gastrectomy performed in patients with early gastric cancer (EGC). This study evaluated conventional risk factors, including gastrectomy, associated with TB development in patients with EGC.

METHODS:  A retrospective cohort study was performed using the database of the Center for Gastric Cancer of the National Cancer Center, Korea. The patients with EGC whose T1 lesions were pathologically confirmed by gastrectomy or endoscopic resection were included.

RESULTS:  A total of 1,935 patients constituted the EGC cohort. Of these, 1,495 patients were confirmed by gastrectomy and the remaining 440 by endoscopic resection. The median follow-up duration was 4.9 years, and during this period, 31 cases of TB developed (TB incidence, 334/100,000 person-years; 95% CI, 227-475). Multivariate Cox regression analysis showed that old TB lesion on chest radiograph and gastrectomy were significant risk factors (hazard ratio [HR], 5.01; 95% CI, 2.44-10.28; P < .001; and HR, 8.95; 95% CI, 1.22-65.78; P = .031; respectively). In the gastrectomy subgroup, old TB lesion and ≥ 15% reduction in weight and albumin level about 1 year after gastrectomy were significant risk factors (HR, 4.80; 95% CI, 2.26-10.18; P < .001; HR, 3.08; 95% CI, 1.47-6.48; P = .003; and HR, 5.02; 95% CI, 1.47-17.12; P = .010; respectively).

CONCLUSIONS:  Old TB lesion and gastrectomy were significant risk factors in the EGC cohort. In addition, old TB lesion and ≥ 15% postoperative reductions in weight and albumin level were significant risk factors in the gastrectomy subgroup.

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