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Diffuse Alveolar Damage in a Patient Receiving DronedaroneDronedarone Lung Toxicity

Shobha Stack, MD, PhD; Dan-Vinh Nguyen, MD; Amanda Casto, MD, PhD; Neera Ahuja, MD
Author and Funding Information

From Stanford University (Drs Stack, Casto, Ahuja), Stanford, CA; and the University of California, Davis (Dr Nguyen), Davis, CA.

CORRESPONDENCE TO: Neera Ahuja, MD, Department of Medicine, 300 Pasteur Dr, Room: S102, MC: 5110, Stanford, CA 94305; e-mail: nkahuja@stanford.edu


Data from this study were reported in a poster presentation at the 2014 Society of General Internal Medicine California-Hawaii Regional Meeting, January 31, 2014, Palo Alto, CA.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;147(4):e131-e133. doi:10.1378/chest.14-1849
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Dronedarone is an amiodarone-like antiarrhythmic with a modified structure. The addition of a methyl sulfonyl group theoretically reduces the toxicity of amiodarone, specifically, adverse thyroid and pulmonary effects. Although animal studies have implicated dronedarone as a cause of lung injury, to date controlled trials in humans have not demonstrated an association. A 68-year-old woman developed a dry cough and worsening respiratory distress after receiving dronedarone for 6 months. Discontinuation of dronedarone therapy and subsequent steroid therapy led to a dramatic improvement of symptoms. Dronedarone may be associated with interstitial lung disease. We believe that patients receiving dronedarone should have their diffusing capacity of lung for carbon monoxide and lung volumes monitored prior to initiation of therapy and frequently thereafter.

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