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Point and Counterpoint |

Rebuttal From Dr DossRebuttal From Dr Doss

Mohan Doss, PhD
Author and Funding Information

From the Department of Diagnostic Imaging, Fox Chase Cancer Center.

CORRESPONDENCE TO: Mohan Doss, PhD, Department of Diagnostic Imaging, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111; e-mail: mohan.doss@fccc.edu


FINANCIAL/NONFINANCIAL DISCLOSURES: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;147(4):878-879. doi:10.1378/chest.14-3023
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Extract

I welcome the opportunity to respond to Dr McCunney.1 His statement in the opening paragraph of his Point editorial that the adverse health effects from ionizing radiation are cumulative does not take into consideration the important effect of the body’s defensive response to low-dose radiation (LDR) exposure. This response, known as adaptive protection, would reduce the endogenous damage that would have occurred in the absence of the LDR exposure, thereby resulting in less overall DNA damage and cancer.2 For example, in a study of 5,000 childhood cancer survivors who had undergone radiation therapy and were followed up for an average of 29 years, the number of second cancers per kg of tissue in the regions of body subjected to radiation dose of about 20 cGy was found to be less than that in the nonirradiated regions of body.3 This observation and additionally cited examples4 involving a variety of LDR exposures demonstrate the effectiveness of LDR given over an extended period of time in reducing the risk of cancers. Thus, his concern about the number of screening CT scans that may be done in the few decades of follow-up of smokers would not be justified.

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