As discussed, the provision of CPR within a high-containment unit poses several challenges in addition to those of code-team composition, response time, and access to emergency equipment. These include limitations to physical dexterity and the introduction of barriers to effective communication related to PPE wear. To heighten awareness of these challenges, we have implemented mock code-simulation training sessions. During these scenarios, the code-team members are asked to perform tasks that are likely to be necessary during a resuscitation effort, such as handling the code cart, drawing up and administering medications, placing defibrillation pads on the patients and delivering shocks. The use of PPE can muffle voices and, therefore, requires extra attention to speak with others at a louder level than usual and with clarity. During this training, we emphasize the need to define clear roles and responsibilities to the team members. Importantly, effective communication is achieved by speaking up and clearly, by making direct eye contact with other members of the team, and by practicing closed-loop communication. Additionally, use of hands-free communication devices can be considered under the powered air-purifying respirator hood (e-Appendix 1: emergency response SOP).