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Allergy and Airway |

The Novel Insights into Associations of Immunoglobulin with Asthma in Adult Patients

Ayass Mohammad
Author and Funding Information

Research, ALC Clinics & Lab, Frisco, TX


Chest. 2014;146(4_MeetingAbstracts):14B. doi:10.1378/chest.1994586
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Abstract

SESSION TITLE: Asthma Posters II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: October 29, 2014 from 1:30 PM to 2:30 PM

PURPOSE: The present study was aimed at a comprehensive analysis of IgA, IgM and IgG levels and their protective or causative association with asthma in adult lung patients. All the adult patients examined at Ayass Lung Clinic & Sleep Center at San Angelo, Texas, who consented for the blood test were included in the study. Socio-demographic, laboratory and clinical information were obtained from medical records. Two hundred and ninety seven asthmatic patients (median age 64 years) were screened for the levels of immunoglobulin. We also studied Ninety seven non- asthmatic patients (median age 70 years) as controls.

METHODS: The present study was aimed at a comprehensive analysis of IgA, IgM and IgG levels and their protective or causative association with asthma in adult lung patients. All the adult patients examined at Ayass Lung Clinic & Sleep Center at San Angelo, Texas, who consented for the blood test were included in the study. Socio-demographic, laboratory and clinical information were obtained from medical records. Two hundred and ninety seven asthmatic patients (median age 64 years) were screened for the levels of immunoglobulin. We also studied Ninety seven non- asthmatic patients (median age 70 years) as controls.

RESULTS: The prevalence of higher IgA>453, IgG>1560, and IgM>305 levels in our study population were, 17%, 17% and 15% respectively. Similarly the higher levels of immunoglobulins IgA, IgG, and IgM as independent risk factors were observed in 62%, 64% and 68% in the asthmatic patients as against 38%, 36% and 32% in the controls. Multivariate logistic regression analysis showed association of asthma with higher level of IgA and IgG after controlling for age, gender and ethnicity were as follow; IgA OR 0.50; 95% CI, 0.28-0.90; P<0.05), IgG OR 0.53; 95% CI, 0.29-0.93; P<0.05. Higher levels of IgA and IgG immunoglobulin were shown to be less likely to develop asthma.

CONCLUSIONS: So higher levels of IgA and IgG are more likely to be protective in terms of development of asthma but additional prospective studies will help to further understand the underlying mechanism of negative association/protection.

CLINICAL IMPLICATIONS: These results indicates that high level of IgG and IgA correlate with asthma and the phenomenon can be utilized in preventive measures through vaccination.

DISCLOSURE: The following authors have nothing to disclose: Mohammad Ayass

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