We agree that noninvasive positive-pressure ventilation (NPPV) following esophagectomy may carry risks that need characterization in future studies. Our study showed variability in the pressure tolerance of anastomoses, as would be expected in the clinical setting. The lowest breaking pressure of 21 cm H2O in one ex vivo sample may be attributable to ischemia of the tissue after explantation. More significant to the clinical setting, the lowest threshold in vivo was 54 cm H2O. Our studies in human cadaveric esophagogastric anastomoses have demonstrated no pressure threshold below 59 cm H2O and a mean pressure threshold of 107 cm H2O (C. P. E., V. R., O. G. Ofoche, BS; unpublished data, January-August 2014). These models help establish the safe parameters for further study of NPPV in patients undergoing esophagectomy.