CGD involves multiple organs, including the lung, lymph node, bone, and GI tract. Pneumonia is the most frequent infection. Most common pathogens are catalase-positive organisms including Aspergillus species, Staphylococcus, Burkholderia species, Serratia, and Nocardia. Patients with CGD may not manifest typical signs of infection, despite the presence of significant infection. In a review of aspergillosis in patients with CGD, one-third of patients are asymptomatic at diagnosis, and only about 20% are febrile. Another important manifestation of CGD is abnormally exuberant inflammatory responses leading to granuloma formation, such as granulomatous enteritis resembling Crohn’s disease.