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Talc Pleurodesis Through Indwelling Pleural Catheters for Malignant Pleural EffusionsTalc Pleurodesis Via Indwelling Pleural Catheters: Retrospective Case Series of a Novel Clinical Pathway

Liju Ahmed, MBBS; Hugh Ip, MBBS; Deepak Rao, MBBS; Nishil Patel, MBBS; Farinaz Noorzad, BSc
Author and Funding Information

From Guy’s and St Thomas’ NHS Trust (Drs Ahmed, Ip, and Rao and Ms Noorzad); and King’s College London (Dr Patel), London, England.

CORRESPONDENCE TO: Hugh Ip, MBBS, Chest Department, 1st Floor, Lambeth Wing, St Thomas’ Hospital, Westminster Bridge Rd, London, SE1 7EH, England; e-mail: Hughip@gmail.com


Drs Ahmed and Ip are joint first authors.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;146(6):e190-e194. doi:10.1378/chest.14-0394
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Malignant pleural effusions cause significant morbidity, but there is no gold standard minimally invasive treatment. A new therapeutic approach combines talc pleurodesis and indwelling pleural catheters (IPCs) to enable outpatient management. This case series summarizes the safety and efficacy data of all patients (24) with a symptomatic malignant pleural effusion who underwent talc pleurodeses via IPCs between December 2010 and July 2013. Successful pleurodesis was achieved in 22 procedures (92%). There was one empyema, one hydropneumothorax, one recurrent effusion, and two minor complications: one drain site wound infection and one complaint of chest pain. Twenty-two procedures (92%) were performed in the outpatient setting. This report confirms the safety and efficacy of administering talc slurry through IPCs in an outpatient setting. Studies in a larger cohort are necessary to define the role of this novel approach in the treatment algorithm of patients with this condition.

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