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Rebuttal From Drs Mermis and SimpsonRebuttal From Drs Mermis and Simpson

Joel D. Mermis, MD; Steven Q. Simpson, MD, FCCP
Author and Funding Information

From the Division of Pulmonary and Critical Care Medicine, University of Kansas School of Medicine.

CORRESPONDENCE TO: Steven Q. Simpson, MD, FCCP, Division of Pulmonary and Critical Care Medicine, University of Kansas School of Medicine, 3901 Rainbow Blvd, Mail Stop 3007, Kansas City, KS 66160; e-mail: ssimpson3@kumc.edu


FINANCIAL/NONFINANCIAL DISCLOSURES: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;146(6):1436-1437. doi:10.1378/chest.14-2226
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Extract

We agree that the pleotropic effects of statins provide mechanistic plausibility for treating critically ill patients. However, over the past decades, we have been baited with mechanistically promising antiinflammatory and other treatments, such as anti-tumor necrosis factor therapies, IL-1ra, and drotrecogin α, which have all failed to benefit patients. We are, sadly, left without specific therapies for common critical illnesses, such as sepsis or ARDS. Understandably, we are eager for new therapies.

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