An elderly woman with a past medical history of hypertension, obesity, hypothyroidism, dyslipidemia, and atrial fibrillation presented to the ED via ambulance with cardiac arrest of unknown etiology. Further history from her family was nonspecific; the patient had experienced generalized malaise, diarrhea, and poor oral intake for several days. Her medications included furosemide, spironolactone, levothyroxine, warfarin, and simvastatin, although this information was unavailable initially. Upon arrival, a pulseless electrical activity (PEA) rhythm was diagnosed, and the patient was endotracheally intubated while CPR and advanced cardiac life support (ACLS) protocols were initiated. Following one round of CPR and resuscitative medications, the patient remained in PEA; thus, a point-of-care echocardiogram from the subcostal window was attempted.