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Atrial Fibrillation During SepsisAtrial Fibrillation During Sepsis: A Determinant of Long-term Outcomes?

Yee C. Lau, MBChB; Gregory Y. H. Lip, MD
Author and Funding Information

From the University of Birmingham Centre for Cardiovascular Sciences, City Hospital.

CORRESPONDENCE TO: Gregory Y. H. Lip, MD, University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Dudley Rd, Birmingham, B18 7QH, England; e-mail: g.y.h.lip@bham.ac.uk


FINANCIAL/NONFINANCIAL DISCLOSURES: The authors have reported to CHEST the following conflicts of interest: Dr Lip has served as a consultant for Bayer AG, Astellas Pharma Inc, Merck & Co, Sanofi SA, Bristol-Myers Squibb Co/Pfizer Inc, Daiichi-Sankyo Co Ltd, Biotronik, Medtronic Inc, Portola Pharmaceuticals Inc, and Boehringer Ingelheim GmbH, and has been on the speakers bureau for Bayer AG, Bristol-Myers Squibb Co/Pfizer Inc, Boehringer Ingelheim GmbH, Daiichi-Sankyo Co Ltd, Medtronic Inc, and Sanofi Aventis US LLC. Dr Lau has reported no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;146(5):1138-1140. doi:10.1378/chest.14-0986
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Despite the advancement of antimicrobial agents, sepsis remains a major global health issue and leading cause of death in low-income countries. In the United States, severe sepsis affects up to 750,000 Americans and is associated with a high mortality rate.1 In severe sepsis, atrial fibrillation (AF) also commonly occurs.2 Sepsis may precipitate AF per se, perhaps unmasking a propensity to develop the arrhythmia, or the association could reflect greater clinical vigilance or monitoring during treatment (or hospitalization) for severe sepsis. Nonetheless, the prognostic effects of sepsis-associated new-onset AF on the subsequent occurrence of AF and long-term outcomes remained uncertain until, in the present issue of CHEST, the article by Walkey et al3 (see page 1187) sheds some light on these questions.

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