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Original Research: Critical Care |

Impact of Diagnostic Criteria on the Incidence of Ventilator-Associated PneumoniaVentilator-Associated Pneumonia Criteria

Amédée Ego, MD; Jean-Charles Preiser, MD, PhD; Jean-Louis Vincent, MD, PhD, FCCP
Author and Funding Information

From the Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.

CORRESPONDENCE TO: Jean-Louis Vincent, MD, PhD, FCCP, Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B-1070 Brussels, Belgium; e-mail: jlvincen@ulb.ac.be


The results of this study were presented in part at the 26th Annual Congress of the European Society of Intensive Care Medicine, October 5-9, 2013, Paris, France.

FUNDING/SUPPORT: The authors have reported to CHEST that no funding was received for this study.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2015;147(2):347-355. doi:10.1378/chest.14-0610
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BACKGROUND:  Ventilator-associated pneumonia (VAP) is a frequent complication of prolonged invasive ventilation. Because VAP is largely preventable, its incidence has been used as an index of quality of care in the ICU. However, the incidence of VAP varies according to which criteria are used to identify it. We compared the incidence of VAP obtained with different sets of criteria.

METHODS:  We collected data from all adult patients admitted to our 35-bed ICU over a 7-month period who had no pulmonary infection on admission or within the first 48 h and who required mechanical ventilation for > 48 h. To diagnose VAP, we applied six published sets of criteria and 89 combinations of criteria for hypoxemia, inflammatory response, purulence of tracheal secretions, chest radiography findings, and microbiologic findings of varying levels of severity. The variables used in each diagnostic algorithm were assessed daily.

RESULTS:  Of 1,824 patients admitted to the ICU during the study period, 91 were eligible for inclusion. The incidence of VAP ranged from 4% to 42% when using the six published sets of criteria and from 0% to 44% when using the 89 combinations. The delay before diagnosis of VAP increased from 4 to 8 days with increasingly stringent criteria, and mortality increased from 50% to 80%.

CONCLUSIONS:  Applying different diagnostic criteria to the same patient population can result in wide variation in the incidence of VAP. The use of different criteria can also influence the time of diagnosis and the associated mortality rate.

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