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Pulmonary Vascular Disease |

Factors Associated With Pulmonary Hypertension in Patients Diagnosed With Chronic Obstructive Pulmonary Disease FREE TO VIEW

Prangthip Charoenpong, MD; Clifton Clarke, MD
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Advocate Illinois Masonic Medical Center, Chicago, IL


Chest. 2014;146(4_MeetingAbstracts):848A. doi:10.1378/chest.1995214
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Abstract

SESSION TITLE: DVT/PE/Pulmonary Hypertension Posters IV

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: COPD can cause secondary pulmonary hypertension(PH). The pathophysiology is chronic inflammation, epithelial dysfunction and hypoxemia. Echocardiography is a non-invasive test that can reveal signs of PH. Multiple studies have been showing that PH worsens the outcome of patients with COPD. Screening lead to early diagnosis and might benefit long term outcome of patients. We sought to examine the risk factors related to PH in COPD patients in order to identify patients who need PH screening.

METHODS: This study is a retrospective review of 136 patients hospitalized for AECOPD in 2011. Out of 136 patients, 73 had echocardiography done during the admission and 22 out of 73 had PH from echocardiography defined by RVSP > 35 mmHg. The demographic data, clinical manifestation, laboratory findings, echocardiographic report including RVSP were collected from medical record. Patients whose LVEF was less than 55% were excluded. Baseline characteristics were compared between PH group and non-PH group.

RESULTS: From 73 patients(70.7±11.8 years old, 50.7 % male), 22 patients were found to have PH(30.1%), whereas 51 patients were in non-PH group. When compared between PH group and non-PH group, the only factors that statistically significant related to PH is hypertension (92.3% vs 72.7%, p=0.034). Obesity (BMI>25) tend to has an association with pulmonary hypertension in COPD (69.2% vs 45.5%, p=0.054). Other factors including sex, diabetes mellitus, dyslipidemia, obstructive sleep apnea (OSA), smoking were not found to have any association with PH in COPD patients.

CONCLUSIONS: Hypertension is the factors associated with PH in COPD patients. Obesity has a trend to relate to PH. We did not find the association between other factors that have been reported to be risk factors for PH such as obesity and history of OSA and this might be explained by small population.

CLINICAL IMPLICATIONS: Screening of PH should be considered in COPD patients especially in who have history of hypertension.

DISCLOSURE: The following authors have nothing to disclose: Prangthip Charoenpong, Clifton Clarke

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