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The Impact of the Arterial Stiffness in a Group of Patients With Orthostatic Hypotension FREE TO VIEW

Paraschiva Postolache, MD; Emilia-Lidia Dumbrava; Doina-Clementina Cojocaru, MD; Cristina-Maria Stănescu, MD
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Rehabilitation Clinic Hospital, Iasi, Romania

Chest. 2014;146(4_MeetingAbstracts):227A. doi:10.1378/chest.1994706
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SESSION TITLE: Non Pulmonary Critical Care Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: Orthostatic intolerance is a syndrome with multiple etiologies, frequently underdiagnosed. Our aim was to evaluate the arterial stiffness in a group of patients with orthostatic hypotension (OH), a form of orthostatic intolerance, and to analyze the impact of this condition on disease evolution.

METHODS: We included 200 consecutive patients (mean age 69.57±11.54), hospitalized in our clinic, which met the diagnosis criteria for OH. All patients were evaluated according to a preset protocol, including the orthostatic tolerance test and evaluation of the carotid intima-media thickness (IMT) both at admission and at the time of discharge. We divided the patients into two sub-groups depending on the presence of the OH at discharge.

RESULTS: The mean value of IMT was higher in the case of the sub-group with persistent OH compared with the control sub-group (1.44±0.52 versus 0.88±0.34), reaching statistical significance (p= 0.001). We note that the number of patients with arterial stiffness was significantly higher in the case of the sub-group with restant OH at discharge compared with the control sub-group (57.4% versus 25.5%), also reaching a statistical significance (p= 0.001).

CONCLUSIONS: The persistence of the OH was related to the presence and the degree of arterial stiffness.

CLINICAL IMPLICATIONS: OH is an independent risk factor for fatal and non-fatal cardiovascular events and also for all-cause mortality, strongly influencing the quality of life. Identifying the pathophysiological mechanisms underlying the occurrence and evolution of orthostatic intolerance and finding ways to investigate them must be a priority, helping us to treat this condition.

DISCLOSURE: The following authors have nothing to disclose: Paraschiva Postolache, Emilia-Lidia Dumbrava, Doina-Clementina Cojocaru, Cristina-Maria Stănescu

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