Allergy and Airway |

Disease Duration and Its Impact on Percentage Predicted FEV1 % in Well-Controlled Asthma Patients FREE TO VIEW

Dipti Gothi; Mayank Saxena; Ram babu Sah
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Department of Pulmonary Medicine, Employees State Insurance - Post Graduate Institute of Medical Sciences and Research, New Delhi, New Delhi, India

Chest. 2014;146(4_MeetingAbstracts):16A. doi:10.1378/chest.1993500
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SESSION TYPE: Original Investigation Slide

PRESENTED ON: Wednesday, October 29, 2014 at 08:45 AM - 10:00 AM

PURPOSE: Asthma control test (ACT) is a reliable and valid method to evaluate lung function. This study analyses the impact of asthma disease duration on percentage predicted forced expiratory volume in 1 second (FEV1 %) in patients who are well controlled (ACT ≥ 20).

METHODS: Spirometry, disease duration and treatment of 71 nonsmoker well controlled bronchial asthma (ACT≥ 20) patients were analysed retrospectively. Patients were divided into 4 groups according to their duration of disease viz. 13 patients in group 1 (< 1 yr), 27 in group 2 (1-5 year), 13 in group 3 (5-10 year), and 18 in group 4 (>10 year). Statistical analysis was done using correlation analysis, unpaired t tests, analysis of variance (ANOVA)

RESULTS: Out of 71 patients 31 (43.6 %) were men and 40 (56.4%) women, their age ranged from 11 to 72 years and asthma symptoms duration ranged from 6 months to 50 years. Primary analysis of data without grouping revealed percentage predicted FEV 1% correlated with age (p = 0.001, r = - 0.381), asthma duration (p = 0.0003, r = - 0.42) and asthma control test (p = 0.03, r = 0.253). Secondary analysis between groups done showed mean percentage predicted FEV1% in group 1: 74.85 ± 8.72, group 2: 75.04 ± 11.47, group 3: 81.38 ± 15.61 and group 4: 58.61 ± 16.22. The difference in percentage predicted FEV1 % in group1, 2 and 3 was statistically insignificant (p = 0.258), whereas that in group 4 was significantly lower (p < 0.0001)

CONCLUSIONS: Patients with higher age and long duration of asthma (>10 years) have significantly lower percentage predicted FEV1 % than of lesser duration disease despite being well controlled (ACT ≥ 20).

CLINICAL IMPLICATIONS: As spirometry does not truly reflect the controlled status, both spirometry and ACT are essential for step-care management of asthma.

DISCLOSURE: The following authors have nothing to disclose: Dipti Gothi, Mayank Saxena, Ram babu Sah

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