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Factors Associated With Mortality Among Tuberculosis Patients in Southeast Turkey FREE TO VIEW

Süreyya Yilmaz; Mahsuk Taylan; Hadice Selimoglu Sen; Özlem Abakay; Zülfükar Yilmaz; Ali ihsan Carkanat; Melike Demir; Fusun Topcu
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Department of Chest Disease and Tuberculosis Dicle University Faculty of Medicine, Diyarbakır, Turkey

Chest. 2014;146(4_MeetingAbstracts):912A. doi:10.1378/chest.1993062
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SESSION TITLE: Respiratory Infections Posters I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: Tuberculosis (TB) is a disease caused by bacillus mycobacterium tuberculosis. Despite effective chemotherapy, it remains significant global health issue. We aimed to investigate the parameters affecting the mortality in patients receiving treatment for tuberculosis.

METHODS: From January 2005 to December 2011, 2450 tuberculosis patients who were followed in tuberculosis dispensaries in the city of Diyarbakir were reviewed retrospectively. Case definitions and treatment outcomes wereclassified according to WHO criteria. Human immunodeficiency virus (HIV) infection were not examined in our patients.

RESULTS: Of the 2450 patients, 1339 were males (54.7%) and 1111 were females (45.3%), with mean age of 32,15±17,87 years. 62.5% of the patients had pulmonary tuberculosis and 37.5% of the patients had extrapulmonary tuberculosis (EPTB). Mortality was significantly increased in patients aged between 56-65 years (p<0,001), in category II (p=0,006), in patients having combination with pulmonary and extra-pulmonary TB (p=0,002), and EPTB alone (p=0,004). When patients compared according to TB location, mortality was significantly increased in gastrointestinal tuberculosis and meningitis (Figure 1). Males had higher mortality rates than females (2,4% vs 1,6%). Besides, relapse patients (5.1%) had a higher mortality rate according to case definitions (Table 1). Twenty-two patients had multi-drug resistant tuberculosis and none of them died.

CONCLUSIONS: Mortality was increased in patients aged between 56-65 years, male gender, relapse, category II and EPTB patients.We suggest that tuberculosis control programs should pay more attention to high-risk groups, and if necessary retreatment regimen for this risk group should be revised.

CLINICAL IMPLICATIONS: We identified factors independently associated with increased mortality following a diagnosis of tuberculosis. We suggest that mortality rate and excess mortality be routinely used as a monitoring tool for evaluating the efficiency of the national control programme.

DISCLOSURE: The following authors have nothing to disclose: Süreyya Yilmaz, Mahsuk Taylan, Hadice Selimoglu Sen, Özlem Abakay, Zülfükar Yilmaz, Ali ihsan Carkanat, Melike Demir, Fusun Topcu

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