Respiratory Care |

Impact of Vitamin D in the Treatment of Tuberculosis FREE TO VIEW

Seda Akalin, MD; Mediha Ortakoylu, MD; Ayse Bahadir, MD; Asuman Kara, MD; Hafize Uzun, MD; Abdülhamid Arikan, MD; Emel Caglar, MD
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Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey

Chest. 2014;146(4_MeetingAbstracts):915A. doi:10.1378/chest.1992758
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SESSION TITLE: Respiratory Infections Posters I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: In our study, it is aimed to be evaluated the effect of 25-OH-vitamin D3 levels in newly diagnosed tuberculosis patients who sputum smear positive to stage of disease and response to the treatment both microbiologically and radiologically.

METHODS: 70 sputum smear positive patients who newly diagnosed between January 2013 and October 2013 are included in the study. In the beginning of the treatment, serum 25-OH-vitamin D3 levels are tested, with complete blood count and other routine blood work of all patients respectively. During the treatment, all patients are followed up. Both microbiologic and radiologic evaluations are done in the beginning, and also in the 1st and 2nd months of treatment. 20 healthy individuals are included as control group fort he comparison of serum 25-OH-vitamin D3 levels. The correlation between the patients’ 25-OH-vitamin D3 and their demographic features, biochemical parameters, sputum smear/culture results and radiologic severity is evaluated.

RESULTS: While the 25-OH-vitamin D3 level in the tuberculosis patients is 22,01 ± 9,24 ng/ml, it is found 37,8 ± 18 ng/ml in healthy individuals. In this case, there is a statistically significant difference between the tuberculosis patients and the control group. When the correlation between the demographic features with biochemical parameters and serum 25-OH-vitamin D3 levels are examined, the correlation between patients’ WBC, HGB, HCT, total protein, albumin and Ca levels and their 25-OH-vitamin D3 levels are found statistically significant. There wasn’t a statistically significant difference between the 25-OH-vitamin D3 levels and sputum smear positive and negative subjects in the 1st and 2nd months of treatment. It is well established that there is a better response to the treatment in the 1st month where the patients have high 25-OH-vitamin D3 levels with radiologic severity.

CONCLUSIONS: In our study, it is demonstrated that active tuberculosis patients have lower 25-OH-vitamin D3 levels compared to the healthy individuals, and it is represented that serum 25-OH-vitamin D3 level may have an influence during the clinical course of tuberculosis.

CLINICAL IMPLICATIONS: Vitamin D may have a role in TB treatment and further investigation is needed.

DISCLOSURE: The following authors have nothing to disclose: Seda Akalin, Mediha Ortakoylu, Ayse Bahadir, Asuman Kara, Hafize Uzun, Abdülhamid Arikan, Emel Caglar

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