Pulmonary Physiology |

Non-Cystic Fibrosis Bronchiectasis Registry FREE TO VIEW

Justin Stocks; Michael Powers; John Parrish, MD
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Naval Medical Center San Diego, San Diego, CA

Chest. 2014;146(4_MeetingAbstracts):717A. doi:10.1378/chest.1992565
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SESSION TITLE: Cystic Fibrosis/Bronchiectasis Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: Identification and characterization of subjects with non-cystic fibrosis bronchiectasis evaluated at a tertiary care Military Medical Center

METHODS: An electronic medical records search was performed to identify all patients with an ICD-9 code for bronchiectasis evaluated in the pulmonary clinic between December 2004 and December 2012. In addition all computed tomography imaging reports obtained during this interval were searched for the term “bronchiectasis” and were included in the study. The registry included demographic data, etiology, lobar location of bronchiectasis, pulmonary function data, sputum cultures, immunoglobulin levels and quantitative rheumatoid factor titers. Subjects were excluded if they did not have evidence of bronchiectasis on body imaging or if they had an established diagnosis of cystic fibrosis.

RESULTS: A total of 2,720 charts were identified by the search criteria. After manual review 818 charts were excluded due to a lack of bronchiectasis on imaging and 16 were excluded for a diagnosis of cystic fibrosis. A total of 1,866 subjects were confirmed to have bronchiectasis. Gender distribution was nearly equal (50.3% female) with a mean age of 67 years. Unlike other US registries Asians/Pacific Islanders comprised nearly 25% of subjects in this cohort. Lobar location patterns of bronchiectasis were available in all patients. The right lower lobe was most frequently affected (49%). Spirometry, plethysmographic lung volumes, and diffusing capacity of carbon monoxide were performed respectively for 990, 703, and 834 patients. Obstruction by spirometry was present in 18% of cases. Over 27,000 individual sputum culture results were included in his registry, and Pseudomonas, staphylococcus and nontuberculous mycobacteria were isolated in the sputum of 176 (9.4%), 153 (8.2%) and 137 (7.3%) subjects respectively.

CONCLUSIONS: Non-cystic fibrosis bronchiectasis afflicts a significant number of patients eligible for care at our tertiary Military Medical Center. Pseudomonas, Staphylococcus and nontuberculous mycobacteria are common pathogens isolated in this population. Pulmonary function testing frequently identified obstruction. To the best of our knowledge this is the largest single-center registry of non-cystic fibrosis bronchiectasis patients in the United States. This cohort will be utilized to further characterize non-cystic fibrosis.

CLINICAL IMPLICATIONS: Hypothesis-generating large registry of non-cystic fibrosis bronchiectasis subjects for future study.

DISCLOSURE: The following authors have nothing to disclose: Justin Stocks, Michael Powers, John Parrish

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