Sleep Disorders |

Progression of Symptoms of Obstructive Sleep Apnea (OSA) and Their Association With Its Severity at Diagnosis? FREE TO VIEW

Swati Gulati; Aiman Tulaimat
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Internal Medicine, John H. Stroger Hospital of Cook County, Chicago, IL

Chest. 2014;146(4_MeetingAbstracts):946A. doi:10.1378/chest.1992430
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: The purpose of the study was to describe the evolution of symptoms of OSA and to determine if the duration of obesity and snoring are better predictors of the severity of sleep apnea than current patient characteristics.

METHODS: Subjects were recruited from the sleep clinic between January 2009 and December 2011 during CPAP set-up. Each patient received a 1) questionnaire about the onset and progression of snoring, apneic episodes, fatigue, breathlessness, excessive daytime sleepiness, leg edema, morning headaches, and depression and 2) a personalized calendar covering 50 years with important personal and national events marked to help recollect accurate timing of symptom onset. Relevant data was collected from the medical record. Standard multivariate regression was used for predictors of AHI.

RESULTS: Average AHI was 62±40. Age at onset of snoring was 28± 15 years, age at onset of apneic spells was 40±15 years and excessive daytime sleepiness started at 42±15 years. The mean age at diagnosis of OSA was 52±13 years.The BMI at age 18 was 26±6 and at the time of diagnosis was 42±10. The age at onset of snoring (p value <0.041) and gain in BMI per year since the age of 18 (p value <0.000) were the strongest predictors of AHI {AHI = 62+ 28(BMI gain/Age-18) -0.76(age at the onset of snoring), R-squared 0.32, R was 0.567)}. The present age, BMI, and gender were not predictors in the regression model.

CONCLUSIONS: There is a significant delay in the diagnosis of OSA and this delay probably contributes to its severity.

CLINICAL IMPLICATIONS: In this sample of patients, significant symptoms of sleep apnea were ignored for at least 20 years by the patients or their physicians. Young adults should be screened for snoring and it should be addressed early to slow its progression to prevent the development of hypertension.

DISCLOSURE: The following authors have nothing to disclose: Swati Gulati, Aiman Tulaimat

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