Diffuse Lung Disease |

Cryptogenic Organizing Pneumonia Presenting as a Cavitary Mass FREE TO VIEW

Joanne Martires, MD; Keren Fogelfeld, MD; Nikhil Barot, MD; Payman Fathizadeh, MD; Nader Kamangar, MD
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UCLA Olive View Medical Center, Sylmar, CA

Chest. 2014;146(4_MeetingAbstracts):394A. doi:10.1378/chest.1992412
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SESSION TITLE: Interstitial Lung Disease Cases II

SESSION TYPE: Affiliate Case Report Slide

PRESENTED ON: Wednesday, October 29, 2014 at 11:00 AM - 12:15 PM

INTRODUCTION: Organizing pneumonia typically presents with patchy, alveolar, and migratory infiltrates on imaging. Other radiographic patterns include diffuse bilateral infiltrates and solitary opacities. Cavitary organizing pneumonia has been described in only a few case reports in the literature. We present a rare case of cryptogenic organizing pneumonia presenting as a cavitary mass.

CASE PRESENTATION: 52 year-old man with history of ischemic cardiomyopathy and diabetes presented with cough with brown sputum, subjective fevers, and shortness of breath for three weeks. He had taken a course of antibiotics without relief. He was originally from El Salvador and had a remote history of smoking. His pulmonary exam was significant for crackles in the right base and mild hypoxemia. He was afebrile and had no leukocytosis. Thoracic imaging was significant for a 5.7 x 5 cm cavitary mass at the right lower lobe with surrounding consolidation and ground glass opacities. The patient underwent a negative infectious workup and there was no evidence of malignancy. Bronchoscopy with transbronchial biopsies revealed multiple fibroplastic plugs (Masson bodies) in the alveoli consistent with organizing pneumonia. The patient was treated with systemic corticosteroids with near resolution of the cavitary mass and marked improvement in symptoms.

DISCUSSION: Organizing pneumonia is characterized by granulation tissue in the lumen of distal airspaces. It is an inflammatory response to alveolar and bronchial damage due an identifiable cause or may be idiopathic. Cavitary organizing pneumonia is very rare. Cavitary masses have a broad differential that includes necrotizing bacterial infections, fungi, mycobacteria, and primary or secondary malignancies. Organizing pneumonia can be an incidental finding in some of these disease processes. Therefore, when organizing pneumonia is found in the workup of a cavitary mass, an extensive workup for a potential underlying cause must be completed. In the case of our patient, no underlying cause of his cavitary mass or organizing pneumonia was identified. He was deemed to have cavitary cryptogenic organizing pneumonia. Histologic findings and his brisk response to steroids confirmed this diagnosis.

CONCLUSIONS: Organizing pneumonia presenting as a cavitary mass is rare and a diagnosis of exclusion; it should be considered in the differential of a cavitary mass.

Reference #1: Epler GR, Colby TV, McLoud TC, et al. Bronchiolitis obliterans organizing pneumonia. N Engl J Med 1985; 312: 152-158.

DISCLOSURE: The following authors have nothing to disclose: Joanne Martires, Keren Fogelfeld, Nikhil Barot, Payman Fathizadeh, Nader Kamangar

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