Diffuse Lung Disease |

Serum Human Cathelicidin Antimicrobial Peptide (CAMP) and D-Vitamin Levels in Patients With Sarcoidosis and Tuberculosis FREE TO VIEW

Ercan Korucu, MD; Mediha Ortakoylu, MD; Ayse Bahadir, MD; Leyla Pür, MD; Asuman Aslan, MD; Hafize Uzun, MD; Burak Önal, MD; Emel Caglar, MD
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Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey

Chest. 2014;146(4_MeetingAbstracts):363A. doi:10.1378/chest.1992329
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SESSION TITLE: Interstitial Lung Disease Posters I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: The clinical, radiological and pathological similarities between sarcoidosis and tuberculosis can make disease differentiation challenging. Patients with sarcoidosis demonstrate antigen-specific immune responses against mycobacterial virulence factors systemically and at sites of active involvement. Recent studies have shown the vitamin D-regulated,human cathelicidin antimicrobial peptide (CAMP) to be important to the immune response against pathogenic mycobacteria.The primary objective of the study was to evaluate the relation between vitamin D nutriture, serum CAMP concentrations in sarcoidosis and tuberculosis (TB) patients

METHODS: Thirty histopathologically-verified sarcoidosis patients with no previous treatment , 30 culture-confirmed pulmonary tuberculosis and 20 healthy controls were included in our study. We measured 25-hydroxyvitamin D [25(OH)D] and CAMP concentrations in serum specimens from patients and healthy .

RESULTS: Mean age was 44.9 ±10.4 in sarcoidosis (21 women,9 men)and,35.6 ±16.2 in tuberculosis(12 women ,18 men)and 42.3±14.5 in controls(6 women ,14 men ). Cathelicidin levels were in sarcoidosis patients and tuberculosis patients and in healthy controls respectively ( 57.87pg/ml, 55.83 pg/ml, 127.65 pg/ml ).There were no significant differences between sarcoidosis and tuberculosis patients but was lower than controls statiscally (p<0.001). D vitamin levels were 11.75±8.9 ng/ml in sarcoidosis , 22.5 ±9.9 ng/ml in tuberculosis patients , and 37.7 ±18.4 ng/ml in control groups.In sarcoidosis group, vitamin D levels was lower than others.The differences between sarcoidosis and tuberculosis patients and controls were statistically significant (p<0.001) .

CONCLUSIONS: As a result,cathelicidin and vitamin D levels decreased in sarcoidosis and tuberculosis groups compared to healthy controls . Our study show that cathelicidn levels are similar in two patients groups but vitamin D insufficiency is the lowest in sarcoidosis one.Little information is available on the clinical relation between vitamin D, CAMP concentrations, and disease severity in patients with tuberculosis or sarcoidosis.

CLINICAL IMPLICATIONS: More prospective studies are needed to evaluate the clinical implications of vitamin D insufficiency and the utility of circulating CAMP as a potential biomarker in patients with sarcoidosis and active tuberculosis disease.

DISCLOSURE: The following authors have nothing to disclose: Ercan Korucu, Mediha Ortakoylu, Ayse Bahadir, Leyla Pür, Asuman Aslan, Hafize Uzun, Burak Önal, Emel Caglar

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