0
Lung Cancer |

Significance of Diffuse Pulmonary Infiltrates in Patients With Lung Cancer

Elvina Khusainova; Robert Lee; Diane Stover
Author and Funding Information

Memorial Sloan Kettering Cancer Center, New York, NY


Chest. 2014;146(4_MeetingAbstracts):602A. doi:10.1378/chest.1992206
Text Size: A A A
Published online

Abstract

SESSION TITLE: Lung Cancer Posters II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: Pulmonary infiltrates in lung cancer patients can represent a number of diagnoses including infectious pneumonia, drug/radiation pneumonitis, and/or progression of disease. Only sparse information is available describing the nature of infiltrates and outcome in this population. We designed a study to further improve understanding of this particular process in lung cancer patients.

METHODS: We performed a retrospective chart review of patients admitted to a major teaching cancer center with a combined diagnosis of abnormal radiograph/pneumonia and lung cancer from January 2008 to December 2010. Data including patient demographics, cancer type and treatment received, hospital course, and survival were reviewed.

RESULTS: A total of 84 admissions in 24 men (44%) and 31 (56%) women were studied. Age on admission ranged from 41 to 87 years old (mean age=66.7). The most common histological type of lung cancer was adenocarcinoma (42%), followed by squamous cell carcinoma (13%). 68% of patients had stage IV lung cancer. In 64 % of cases patients received chemotherapy and/or radiation treatment in the preceding 3 months. The mean hospital stay was 8 days (range 3 days to 60 days). In 42% of cases radiographs were consistent with bilateral infiltrates. 35% of unilateral infiltrates were ipsilateral to the site of original lung cancer. 12% of admissions led to respiratory failure requiring mechanical ventilation. In 85% of cases microbiologic work up yielded no specific causative organism. All patients received antibiotics. Bronchoscopy was performed in 11% of all cases, with three cases showing progression of disease. 85% of admissions led to home discharge. Five patients were discharged to hospice, eight patients died in the hospital.

CONCLUSIONS: Etiology of pulmonary infiltrates remained unclear in the majority of lung cancer patients. Bilateral infiltrates did not lead to worsening outcome since most deaths occurred in patients with unilateral infiltrates. Respiratory failure requiring intubation on initial presentation was an indicator for mortality during hospitalization. Although bronchoscopy was rarely performed, when it was, it showed clinically significant findings, such as progression of disease.

CLINICAL IMPLICATIONS: Since the majority of patients with lung cancer had a good outcome, they should be aggressively treated when presenting with new pulmonary infiltrates. When clinically appropriate, bronchoscopy should be performed as it may reveal significant findings such as progression of disease.

DISCLOSURE: The following authors have nothing to disclose: Elvina Khusainova, Robert Lee, Diane Stover

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543