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Pediatrics |

Impact of Childhood Asthma on Lung Function at 21 Years: Findings From a Longitudinal Birth Cohort Study

Sadasivam Suresh; Abdullah Mamun; Michael O'callaghan; Peter Sly, PhD
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School of Population Health, University of Queensland, Chapel Hill, QLD, Australia


Chest. 2014;146(4_MeetingAbstracts):704A. doi:10.1378/chest.1991992
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Abstract

SESSION TITLE: Pediatic Pulmonary & Critical Care

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Monday, October 27, 2014 at 04:30 PM - 05:30 PM

PURPOSE: To assess the influence of childhood asthma on lung function at 21 years in a longitudinal birth cohort.

METHODS: Data from a 21-year follow-up of mothers and their children recruited into the Mater-University of Queensland Study of Pregnancy. This study is based on a sub-sample of 2172 young adults (49% males) who had prospective data available on self-reported childhood asthma at age 5, 14 and 21 yr and respiratory function at 21 years. Lung function variables measured were FVC, FEV1 & FEF25-75. Analysis of variance was used to estimate the mean difference in lung function, separately for males and females.

RESULTS: Lung function and childhood asthma data were available for 2172 subjects. There was statistically significant difference in both FVC [male 5.43 v 5.32; p<0.05, female 3.87 v 3.82] & FEV1 [male 4.63 v 4.42; p<0.05, female 3.39 v 3.28; p<0.05] between subjects who never reported asthma to subjects who have had asthma during the reporting period. Analysing different subsets of asthma presentation suggest amongst the asthma subjects late onset asthma appears to have the least reduction in their lung function. Asthma group - Male: FVC L (sd), FEV1 L/m (sd), Female: FVC L (sd), FEV1 L/m (sd) No asthma - 5.43 (.83)*, 4.63 (.65)*, 3.87 (.58), 3.39 (.44)* Asthma at 5, 14 & 21 yrs - 5.25 (.78), 4.18 (.66), 3.83 (.45), 3.20 (.41) Adult onset asthma [21 yrs] - 5.40 (.85), 4.50 (.63), 3.80 (.54), 3.32 (.40) Late onset asthma [14 & 21 yrs] - 5.34 (.78), 4.44 (.66), 3.80 (.65), 3.26 (.50) Childhood only asthma [5, 14, 5&14 yrs] - 5.25(.49), 4.48 (.64), 3.98 (.66), 3.41 (.54) * indicates statistically significant with p<0.05

CONCLUSIONS: Asthma that is present during childhood appears to have an impact on the peak lung function achieved. Marked differences are noted in FEV1 in both gender and FVC in males. Asthma that occurs later [14yrs and after] appears to have the least impact on the lung function differences.

CLINICAL IMPLICATIONS: These findings suggest that the impact of asthma on lung function is marked to the first few years of life and greatest impact on the calibre of the airways [FEV1] and less so on lung volume [FVC].

DISCLOSURE: The following authors have nothing to disclose: Sadasivam Suresh, Abdullah Mamun, Michael O'callaghan, Peter Sly

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