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Cardiovascular Disease |

Association of ABO Blood Types With the Risk of In-Stent Restenosis FREE TO VIEW

Leili Pourafkari, MD; Samad Ghaffari, MD; Arezou Tajlil, MD; Mojan Ahmadi, MD; Nader Nader, PhD
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Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran


Chest. 2014;146(4_MeetingAbstracts):123A. doi:10.1378/chest.1991829
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Abstract

SESSION TITLE: CAD/Coronary Syndromes Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: To investigate the prevalence of in-stent restenosis (ISR) in patients with various ABO blood types.

METHODS: Clinical information from 150 patients with confirmed diagnosis of ISR and 150 patients with diagnosis of patent coronary stents in the secondary angiography was collected. Comprehensive demographic and laboratory data, including ABO and Rhesus blood groups as well as comorbid conditions, vessel and stent characteristics were recorded for each patient. Association of ABO blood groups with the risk of ISR before and after controlling for coronary risk factors was determined. Categorical data were analyzed with chi-square test and numerical values were analyzed with t-tests. Binary logistic regression models were constructed to compare type A and non-A for the frequency of risk factors.

RESULTS: A total of 392 stents were implanted in 300 patients. 214 stents (54.6%) were patent and 178 stents (45.4%) were stenosed. Blood group A was significantly more common in the ISR group (43.3%vs. 28.7%, P=0.03). However, the frequencies of other blood types as well as Rh antigen were similar between the two groups. Triglyceride and low-density lipoproteins were the only significantly different variables. (221±198mg/dl, vs. 138±76mg/dl, P<0.001 and 108±36mg/dl vs. 96±73mg/dl, P=0.04, in type-A vs. non-A, respectively). After matching for coronary risk factors, there was no difference between A blood type patients and their controls.

CONCLUSIONS: ISR is significantly more prevalent in individuals with type A blood group. However, this higher association is most likely due to higher atherogenic conditions in patients with this population.

CLINICAL IMPLICATIONS: We have shown an association between type-A blood and restenosis of the stents placed for coronary occlusive disease. In univariate analyses there was a 38% increase in the likelihood of in-stent restenosis in type A blood group compared to the patients with blood types other than type-A.

DISCLOSURE: The following authors have nothing to disclose: Leili Pourafkari, Samad Ghaffari, Arezou Tajlil, Mojan Ahmadi, Nader Nader

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