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Allergy and Airway |

Proinflammatory Lymphocytic Profile in Chronic Obstructive Pulmonary Disease (COPD) Patients

Halina Batura-Gabryel, MD; Beata Brajer-Luftmann, MD; Agata Nowicka, PhD; Mariusz Kaczmarek, PhD; Jan Sikora, PhD
Author and Funding Information

University of Medical Science, Department of Pulmonology, Poznan, Poland


Chest. 2014;146(4_MeetingAbstracts):60A. doi:10.1378/chest.1991580
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Abstract

SESSION TITLE: COPD Biomarkers

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Monday, October 27, 2014 at 07:30 AM - 08:30 AM

PURPOSE: COPD is an independent risk factor for lung cancer. The pathogenesis of both diseases plays a crucial role specific microenvironment created by chronic inflammation. COPD is characterized by increased accumulation of granulocytes, macrophages, lymphocytes and dendritic cells. Little is known about the impact of COPD on the microenvironment of different subpopulations of T lymphocytes other than Th1 i Th2 (Th9, Th17, Th22). Their role in the pathogenesis of diseases in which inflammation is a substrate depends on the specific secretion of mediators, such as IL-17, which promotes secretion by the respiratory epithelium chemokines CXCL1, CXCL6, CXCL8 receptor ligands which CXCR2 and GM-CSF i G-CSF. These factors affect the survival of neutrophils, which are becoming important drivers of promoting them dependent inflammation in COPD. In contrast, for the maintenance of peripheral immune tolerance are responsible, among others, regulatory T cells. The aim: To attempt to characterize the pro-inflammatory microenvironment in the course of COPD in terms of lymphocyte profile.

METHODS: We reviewed cytometric evaluation immunophenotyping bronchial lavage (BAL) and peripheral blood collected from 17 patients with COPD.

RESULTS: In assessing the profile of lymphocyte in peripheral blood and BAL revealed the presence of lymphocytes Th1 (CCR5), Th17 (CCR6), Th22 (CCR10) and T reg. It has been shown a higher percentage of Th1, Th17 and Th22 in peripheral blood, in BAL higher percentage of lymphocytes T reg.

CONCLUSIONS: The attempt to characterize the pro-inflammatory microenvironment in the course of COPD in terms of lymphocyte profile confirms the presence of an active peripheral and local inflammatory process in the field of lymphocyte profile. Further work is necessary taking into account the profile of monocyte, granulocyte and granulocyte and lymphocyte regulatory cells.

CLINICAL IMPLICATIONS: The preliminary results of this study and its continuation in the future mays allow a more accurate assessment of inflammation and predisposition to carcinogenesis in COPD patients

DISCLOSURE: The following authors have nothing to disclose: Halina Batura-Gabryel, Beata Brajer-Luftmann, Agata Nowicka, Mariusz Kaczmarek, Jan Sikora

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