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Occupational and Environmental Lung Diseases |

"Natural History" of Gas Exchange in the Development of Morbid Obesity

Santos-Martínez Luis-Efren, MD; Leticia Gómez-López, RT; Javier Quevedo-Paredes, RT; Adrian Arias-Jiménez, RT; Patricia Osorio-Avila, RT; Armando Nielzer Rodríguez-Almendros, MD; Irma Flores-Colín, MD; Moisés Cuttiel Calderón-Abbo, MD
Author and Funding Information

Instituto Mexicano del Seguro Social, Mexico, DF, Mexico


Chest. 2014;146(4_MeetingAbstracts):684A. doi:10.1378/chest.1991268
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Abstract

SESSION TITLE: Occupational/Environmental Lung Disease Posters

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: To determine differences in variables related to gas exchange in the development of morbid obesity categorized according to body mass index.

METHODS: Using cross-sectional design, four groups of subjects with varying degrees of increased body mass index (normal (18.50-24.99), overweight (25-29.99), obesity (30-39.99) and morbid obesity (≥ 40) Kg/m2) were studied. The subjects were assessed their demographic background, simple spirometry and arterial blood gases. The study was approved by the research committee of the unit. Data are presented with mean±standard deviation, differences were established with one-way ANOVA with Bonferroni test. p <0.05 was accepted for statistical significance.

RESULTS: 560 subjects were studied, 140 in each group 70 men and 70 women. Mean age 49±11 years. Occupations, home (26%), sales (11%) and truck driver (7%). The observed differences in pH (7.41 ± 0.02 vs. 7.42 ± 0.02 vs. 7.42 ± 0.03 vs. 7.39 ± 0.25), arterial oxygen pressure (68.28 ± 6.06 vs. 67.54 ± 9.33 vs. 65.53 ± 9.27 vs .59.86 ± 9.28 mmHg), carbon dioxide (31.37 ± 2.08 vs. 34.79 ± 4.38 vs. 37.86 ± 4.21 vs. 38.14 ± 5.10 mmHg), hemoglobin (13.92 ± 1.45 vs. 13.97 ± 1.73 vs. 14.82 ± 1.71 vs. 15.24 ± 1.83 g / dl), p <0.05. Simple spirometry, forced expiratory volume in 1 second (FEV1)% (93.73±6.83 vs. 93.15±7.36 vs. 91.63±5.48 vs. 87.09±4.55), forced vital capacity (FVC)% 87.13±6.52 vs. 87.01 ± 5.98 vs. 85.96±6.73 vs. 72.75±13.91, FEV1/FVC ratio,% (85.06±5 vs. 87.59 ± 4.05 vs. 84.02 ± 4.64 vs. 87.48±18.66), p <0.05.

CONCLUSIONS: Alterations in gas exchange appear to initiate from overweight and is evident in the morbid obesity

CLINICAL IMPLICATIONS: Disorders in gas exchange in the morbid obese patients have been published previously; however, gas exchange behavior is unknown in the development of morbid obesity.

DISCLOSURE: The following authors have nothing to disclose: Santos-Martínez Luis-Efren, Leticia Gómez-López, Javier Quevedo-Paredes, Adrian Arias-Jiménez, Patricia Osorio-Avila, Armando Nielzer Rodríguez-Almendros, Irma Flores-Colín, Moisés Cuttiel Calderón-Abbo

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