0
Lung Cancer |

Metastatic Digital Sweat Gland Carcinoma Simulating Recurrent Lung Carcinoma

Bartosz Buchcic, MD; Dr. Odile David, MD; Dr H. Ari Jaffe, MD
Author and Funding Information

University of Illinois, Chicago, IL


Chest. 2014;146(4_MeetingAbstracts):615A. doi:10.1378/chest.1988059
Text Size: A A A
Published online

Abstract

SESSION TITLE: Cancer Case Report Posters I

SESSION TYPE: Affiliate Case Report Poster

PRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PM

INTRODUCTION: Sweat gland carcinoma, first described in 18651, is a rare malignancy with a varying histology and complex classification. Diagnosis is often delayed due to low incidence and confusion with other skin tumors and cutaneous metastases from visceral malignancies. We present a case with simultaneous digital and lung masses in a patient with prior history of resected squamous cell lung cancer.

CASE PRESENTATION: A 77-year-old woman with 50 pack year history of smoking and previous squamous cell cancer (pT1aN0), s/p RML lobectomy, but without radiation or chemotherapy, re-presented after 3 years with a 3 month history of a painful, growing and ulcerated digital mass [Fig.1] but no respiratory symptoms. Imaging showed edema and bone destruction. CXR revealed a large RUL mass and prior operative changes. PET/CT documented 18FDG avidity in the finger (SUV 19.6), an 8.5 x 7.5 cm RUL mass abutting the pleural surface with extension to the hilum (SUV 26.5) and right hilar adenopathy (SUV 16.7) [Fig.2]. The resected digital mass revealed poorly differentiated sweat gland carcinoma (pT2Nx) [Fig.3]. The lung mass biopsy confirmed metastatic sweat gland carcinoma [Fig.4], as it was histologically similar to the digital mass and distinctly different from the original lung cancer. The patient declined surgical evaluation and is being treated with concurrent chemo- and radiation therapy.

DISCUSSION: Sweat gland carcinomas are uncommon with incidence of 0.005 percent of epithelial malignancies2. Age at presentation varies, with most occurring in the later decades. Most grow slowly but rarely, rapidly and aggressively with metastases involving lymph nodes, bones, liver, lungs and skin. Clinical behavior correlates with histology, degree of differentiation, and clinical stage. Definitive data are lacking regarding recurrence, prognosis and treatment3.

CONCLUSIONS: Lung masses occurring in the context of sweat gland carcinoma may represent metastatic disease even in patients with prior lung cancer and significant tobacco exposure. Currently, there is no consensus on treatment beyond wide local excision.

Reference #1: Coril, V. Contributions a l'histoire du developpement histologique des tumeurs epitheliales. J. de l'anat. et physiol., I865, 2, 266-276

Reference #2: Hall J, et. al. Sweat-gland Tumours: A Clinical Review of Cases in One Centre Over 20 Year. Clinical Oncology (2006) 18:351-359

Reference #3: Nidal A Obaidat, et. al. Skin adnexal neoplasms—part 2: An approach to tumours of cutaneous sweat glands J Clin Pathol 2007;60:145-159

DISCLOSURE: The following authors have nothing to disclose: Bartosz Buchcic, Dr. Odile David, Dr H. Ari Jaffe

No Product/Research Disclosure Information


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Primary cutaneous mucinous carcinoma of the penis. Can Urol Assoc J ;8(1-2):E89-91.
Primary epithelial myoepithelial lung carcinoma. Korean J Thorac Cardiovasc Surg 2014;47(1):59-62.
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543