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Allergy and Airway |

Serum Angiopoietin Is Associated With Lung Function in Patients With Asthma

An Soo Jang; PuReun-HaNeul Lee, MD; Kuk-Young Moon; Sung-Woo Park; Ae-Rin Baek; Do-Jin Kim; Choon-Sik Park
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Soonchunhyang University Hospital, Bucheon, Republic of Korea


Chest. 2014;146(4_MeetingAbstracts):9A. doi:10.1378/chest.1976057
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Abstract

SESSION TITLE: Asthma Posters I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: Angiopoietin-1 (ANGPT1) is an essential mediator of angiogenesis that establishes vascular integrity, and angiopoietin-2 (ANGPT2) acts as its natural inhibitor. We considered that angiopoietin might be important in bronchial asthma.

METHODS: Thirty-five patients with asthma and 20 healthy subjects were studied using ELISA.

RESULTS: ANGPT1 levels were significantly elevated in patients with asthma compared to control subjects (293.9 ± 13.8 pg/ml vs. 248.3 ± 16.2 pg/ml, p=0.04). The area under the curve (AUC) for serum angiopoietin revealed that the level of ANGPT1 (0.68) was more sensitive and specific than the determination of ANGPT2 levels (0.55) for differentiating patients with asthma from control subjects. ANGPT2 levels were not different between the two groups. The ANGPT1/ANGPT2 ratio correlated with FEV1/FVC (r=-0.312, p=0.02). ANGPT2 correlated with body mass index.

CONCLUSIONS: Our results reveal that ANGPT1 levels were higher in asthma patients compared with healthy subjects. Because the ANGPT1/ANGPT2 ratio was related to lung function, the data suggest that serum angiopoietin may be associated with lung function in patients with asthma.

CLINICAL IMPLICATIONS: Serum angiopoietin may be a marker for asthma evaluation and monitor.

DISCLOSURE: The following authors have nothing to disclose: An Soo Jang, PuReun-HaNeul Lee, Kuk-Young Moon, Sung-Woo Park, Ae-Rin Baek, Do-Jin Kim, Choon-Sik Park

disscus as done


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