Allergy and Airway |

Spirometric Response to Bronchial Thermoplasty in Patients With Severe Asthma FREE TO VIEW

Andrew Porter; Brent Brown
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University of Oklahoma, Oklahoma City, OK

Chest. 2014;146(4_MeetingAbstracts):10A. doi:10.1378/chest.1971101
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SESSION TITLE: Asthma Posters I

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PM

PURPOSE: Bronchial thermoplasty is an FDA approved procedure for the treatment of severe asthma. Previous studies have not documented an improvement in FEV1 or FVC after thermoplasty, although these studies did not enroll patients with moderate to severe obstruction on spirometry. We sought to determine the effect of bronchial thermoplasty on pulmonary function in patients with documented obstruction on spirometry.

METHODS: Baseline spirometric data from severe asthma patients who underwent bronchial thermoplasty were compared to data obtained one to three months after the procedure.

RESULTS: All patients had a preprocedure FEV1 of less than 60%. In all five patients, FEV1 and FVC improved after the procedure. Mean FEV1 preprocedure was 52% (range 46-60%) predicted, which improved to 67% (range 54-77%) predicted (p=0.02). Mean FVC preprocedure was 76% (range 63-107%) predicted which improved to 88% (range 70-109%) predicted (p=0.03).

CONCLUSIONS: This small observational study indicates that bronchial thermoplasty can improve spirometric values in those patients who have moderate to severe obstruction.

CLINICAL IMPLICATIONS: Bronchial thermoplasty can improve spirometry as well as asthma control and asthma quality of life in patients with severe asthma and moderate to severe obstruction.

DISCLOSURE: The following authors have nothing to disclose: Andrew Porter, Brent Brown

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