0
Point and Counterpoint |

Counterpoint: Is an Increase in FEV1 and/or FVC ≥ 12% of Control and ≥ 200 mL the Best Way to Assess Positive Bronchodilator Response? NoFEV1 for Bronchodilator Response? No

James E. Hansen, MD, FCCP; Janos Porszasz, MD, PhD
Author and Funding Information

From the David Geffen School of Medicine at UCLA and Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center.

CORRESPONDENCE TO: James E. Hansen, MD, FCCP, Department of Medicine, Harbor-UCLA Medical Center, Box 405, Torrance, CA 90502; e-mail: jhansen @labiomed.org


FINANCIAL/NONFINANCIAL DISCLOSURES: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;146(3):538-541. doi:10.1378/chest.14-0437
Text Size: A A A
Published online

Extract

We respect the integrity, intelligence, and experience of the experts serving on the American Thoracic Society/European Respiratory Society (ATS/ERS) pulmonary function committees1 and Tan et al2 and the validity of their data. However, we do not agree with some of their statistical analyses and interpretations of bronchodilator responsiveness. Table 9 of the ATS/ERS document states: “An increase in FEV1 and/or FVC ≥ 12% and ≥ 200 mL constitutes a positive bronchodilator response.”1 Relevant portions of this document use the terms “meaningful” and “significant” without using the term “statistically significant” (SS).

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543