0
Point and Counterpoint |

Point: Is an Increase in FEV1 and/or FVC ≥ 12% of Control and ≥ 200 mL the Best Way to Assess Positive Bronchodilator Response? YesFEV1 for Bronchodilator Response? Yes

Riccardo Pellegrino, MD; Vito Brusasco, MD
Author and Funding Information

From the Allergologia e Fisiopatologia Respiratoria (Dr Pellegrino) and Dipartimento di Medicina Interna e Specialità Mediche (Dr Brusasco), Scuola di Scienze Mediche e Farmaceutiche, Università di Genova.

CORRESPONDENCE TO: Riccardo Pellegrino, MD, Allergologia and Fisiopatologia Respiratoria, ASO S Croce e Carle, 12100 Cuneo, Italy; e-mail: pellegrino.r@ospedale.cuneo.it


FINANCIAL/NONFINANCIAL DISCLOSURES: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;146(3):536-537. doi:10.1378/chest.14-0810
Text Size: A A A
Published online

Extract

According to the American Thoracic Society/European Respiratory Society document on lung function testing, FEV1 and FVC are the key parameters to assess bronchoreversibility in obstructive lung diseases because spirometry is easy to perform in any setting, repeatable and reproducible, and, thus, suitable to assess either intraday or long-term changes in lung function.1 The acute response to bronchodilators is relatively easy to interpret when changes in FEV1 or FVC exceed the thresholds of their natural intraday variability (ie, 12% of baseline and 200 mL), thus, unequivocally indicating bronchodilation. Although the bronchodilator response does not allow a distinction between bronchial asthma and COPD,2,3 large responses can be taken as strongly suggestive of the former.4 Therefore, we believe that changes in FEV1 or FVC still represent the most suitable first-line method to assess bronchodilator response in clinical practice.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543