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Sleep Apnea and Ectopic Fat DepositionSleep Apnea and Ectopic Fat Deposition FREE TO VIEW

Aibek E. Mirrakhimov, MD; Erkin M. Mirrakhimov, MD, PhD
Author and Funding Information

From the Department of Internal Medicine (Dr A. E. Mirrakhimov), Saint Joseph Hospital; and Kyrgyz State Medical Academy (Dr E. M. Mirrakhimov).

CORRESPONDENCE TO: Aibek E. Mirrakhimov, MD, Saint Joseph Hospital, Department of Internal Medicine, 2900 N Lake Shore Dr, Chicago, IL 60657; e-mail: amirrakhimov1@gmail.com


FINANCIAL/NONFINANCIAL DISCLOSURES: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;146(2):e67. doi:10.1378/chest.14-0627
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Published online
To the Editor:

We read the recently published article in CHEST (March 2014) by Minville et al1 with a great interest. The authors demonstrated that OSA and, more specifically, severity of nocturnal hypoxia were significantly associated with ectopic fat deposition in the liver.

Indeed, as pointed out by the authors, OSA is linked to a multitude of derangements of metabolism, including diabetes mellitus, hyperlipidemia, and others. It is essential to understand whether OSA-targeted therapy will prevent or halt the development of associated cardiometabolic conditions. One potential way to do this is to detect populations at risk at early stages, when the impact of OSA therapy on the development and/or progression of comorbid conditions may be the greatest. Recent research data suggest that ectopic fat deposition in the pancreas precedes a similar process in the liver.2 Nonalcoholic fatty pancreatic disease (NAFPD) is strongly linked to metabolic abnormalities, similar to nonalcoholic fatty liver disease.3 Given the possibility that NAFPD may be an earlier manifestation of excessive metabolic risk, it might be useful to study whether OSA is more common in this group than in people without NAFPD.4 If this is found to be true, further research should focus on whether OSA treatment would lead to resolution of NAFPD and, more importantly, beneficially impact the metabolic profile.

References

Minville C, Hilleret M-N, Tamisier R, et al. Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea. Chest. 2014;145(3):525-533. [CrossRef] [PubMed]
 
Wu WC, Wang CY. Association between non-alcoholic fatty pancreatic disease (NAFPD) and the metabolic syndrome: case-control retrospective study. Cardiovasc Diabetol. 2013;12:77. [CrossRef] [PubMed]
 
Wang CY, Ou HY, Chen MF, Chang TC, Chang CJ. Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population. J Am Heart Assoc. 2014;3(1):e000297. [CrossRef] [PubMed]
 
Mirrakhimov AE. Nonalcoholic fatty pancreatic disease and cardio-metabolic risk: is there is a place for obstructive sleep apnea? Cardiovasc Diabetol. 2014;13:29. [CrossRef] [PubMed]
 

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References

Minville C, Hilleret M-N, Tamisier R, et al. Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea. Chest. 2014;145(3):525-533. [CrossRef] [PubMed]
 
Wu WC, Wang CY. Association between non-alcoholic fatty pancreatic disease (NAFPD) and the metabolic syndrome: case-control retrospective study. Cardiovasc Diabetol. 2013;12:77. [CrossRef] [PubMed]
 
Wang CY, Ou HY, Chen MF, Chang TC, Chang CJ. Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population. J Am Heart Assoc. 2014;3(1):e000297. [CrossRef] [PubMed]
 
Mirrakhimov AE. Nonalcoholic fatty pancreatic disease and cardio-metabolic risk: is there is a place for obstructive sleep apnea? Cardiovasc Diabetol. 2014;13:29. [CrossRef] [PubMed]
 
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