The clinical picture is variable, ranging from subclinical infection to rapidly fatal disease. Pneumonia is the most common clinical manifestation of the disease, followed by localized skin infection. Septic arthritis as the presenting manifestation of the disease is uncommon. Bacteremia and septic shock are present in about one-half and one-quarter of patients, respectively, with a high mortality rate in the latter. Melioidosis can be confused with other infections, especially TB, as they share similar geographic distribution, clinical and radiologic manifestations, latent and active status, and multiorgan affection. Concurrent infection with both has also been reported. Common radiologic features of melioidosis include patchy consolidation, cavitation, nodules, effusion, and abscesses. The latter can also be found in the liver, spleen, prostate, or kidneys.