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Pulmonary Arterial Hypertension Treatment GuidelinesNew Guidelines for Pulmonary Arterial Hypertension: New Answers and Even More Questions

Anna R. Hemnes, MD
Author and Funding Information

From the Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine.

CORRESPONDENCE TO: Anna R. Hemnes, MD, Division of Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; e-mail: anna.r.hemnes@vanderbilt.edu


FINANCIAL/NONFINANCIAL DISCLOSURES: The author has reported to CHEST the following conflicts of interest: Dr Hemnes has served as a consultant to Bayer, Pfizer Inc, and United Therapeutics Corp. She has received research funding from United Therapeutics Corp and the National Institutes of Health.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;146(2):239-241. doi:10.1378/chest.14-1440
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I vividly remember my first patient with pulmonary arterial hypertension (PAH) during my internship in 1999. We admitted a young woman with pulmonary hypertension, clearly miserable from right-sided heart failure. Although she had been followed in our pulmonary hypertension clinic, there was little to offer her until she clearly required the only medication that was known to be efficacious in patients with PAH at that time: IV epoprostenol.1 Within a few days of starting therapy, she was a new person: walking through the hall, heart failure resolved, and ready to go home to her family. The drug was unquestionably life saving, but at the same time, it was bittersweet that the only therapy available then required continuous infusion for the rest of her life and had many undesirable side effects.

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