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Contemporary Reviews in Sleep Medicine |

Sleep-Disordered Breathing in Hypertrophic CardiomyopathySleep Apnea and Hypertrophic Cardiomyopathy: Challenges and Opportunities

Tomas Konecny, MD, PhD; Virend K. Somers, MD, DPhil, FCCP
Author and Funding Information

From the Mayo Clinic (Drs Konecny and Somers), Rochester, MN; and International Clinical Research Center (Dr Konecny), St Anne’s Hospital, Brno, Czech Republic.

CORRESPONDENCE TO: Tomas Konecny, MD, PhD, Mayo Clinic, Division of Cardiovascular Diseases, 200 First St SW, Rochester, MN 55905; e-mail: konecny.tomas@mayo.edu


FUNDING/SUPPORT: This study was supported by the Mayo Clinic Foundation; the National Institutes of Health [Grant HL65176]; the European Regional Development Fund [Grant CZ.1.05/1.1.00/02.0123]; and the Internal Grant Agency, Ministry of Health, Czech Republic [Grants NT11401-5/2011 and CZ.1.07/2.3.00/20.0022].

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;146(1):228-234. doi:10.1378/chest.14-0084
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Sleep-disordered breathing (SDB) may be a treatable risk factor in patients with hypertrophic cardiomyopathy (HCM), the most common inherited cardiomyopathy. Evidence suggests a high prevalence of SDB in HCM. We summarize the pathophysiology of SDB as it relates to hypertension, coronary artery disease, atrial fibrillation, and sudden cardiac death in patients with HCM. The implications regarding the care of patients with HCM and SDB are discussed as well as the knowledge deficits needing further exploration.

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