We thank Dr Chang and colleagues for their interest and comments on our review of immunohistochemistry in lung and pleural neoplasms.1 We agree with their remarks. Cytokeratins (CKs) are numbered based on their electrophoretic mobility. As Dr Chang and colleagues correctly point out, CAM5.2 is often mistakenly considered to identify CKs 8 and 18. CAM5.2 clones that are currently used are antibodies to CK8 and do not identify CK18. Antibodies that identify both CKs 8 and 18 are a CK8/18 cocktail and MAK-6 (identifies CKs 8/14/15/16/18/19).2 Both CAM5.2 and CK8/18 are commonly used to identify epithelial lineage in malignant neoplasms.