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Haresh Mani, MD; Dani S. Zander, MD
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From the Department of Pathology, Penn State Milton S. Hershey Medical Center/Penn State College of Medicine.

Correspondence to: Haresh Mani, MD, Department of Pathology, Penn State Milton S. Hershey Medical Center/Penn State College of Medicine, PO Box 850, 500 University Dr, Hershey, PA 17033-0850; e-mail: hmani@lycos.com


Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;145(6):1442. doi:10.1378/chest.14-0808
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To the Editor:

We thank Dr Chang and colleagues for their interest and comments on our review of immunohistochemistry in lung and pleural neoplasms.1 We agree with their remarks. Cytokeratins (CKs) are numbered based on their electrophoretic mobility. As Dr Chang and colleagues correctly point out, CAM5.2 is often mistakenly considered to identify CKs 8 and 18. CAM5.2 clones that are currently used are antibodies to CK8 and do not identify CK18. Antibodies that identify both CKs 8 and 18 are a CK8/18 cocktail and MAK-6 (identifies CKs 8/14/15/16/18/19).2 Both CAM5.2 and CK8/18 are commonly used to identify epithelial lineage in malignant neoplasms.

References

Mani H, Zander DS. Immunohistochemistry: applications to the evaluation of lung and pleural neoplasms: part 1. Chest. 2012;142(5):1316-1323.
 
Bhargava R, Dabbs DJ. Immunohistology of metastatic carcinoma of unknown primary site.. In:Dabbs DJ., ed. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications.4th ed. Philadelphia, PA: Elsevier Saunders; 2014:213.
 

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References

Mani H, Zander DS. Immunohistochemistry: applications to the evaluation of lung and pleural neoplasms: part 1. Chest. 2012;142(5):1316-1323.
 
Bhargava R, Dabbs DJ. Immunohistology of metastatic carcinoma of unknown primary site.. In:Dabbs DJ., ed. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications.4th ed. Philadelphia, PA: Elsevier Saunders; 2014:213.
 
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