Presenting symptoms are nonspecific and include cough, dyspnea, and, occasionally, hemoptysis. Patients are often treated for recurrent pneumonia, tracheobronchitis, or asthma prior to diagnosis. Respiratory symptoms result from progressive airway narrowing. Tracheobronchial amyloidosis may be confused with bronchial asthma, airways neoplasm, and, rarely, relapsing polychrondritis, and can result in atelectasis or postobstructive pneumonia. In addition, calcified or cartilaginous submucosal nodules may be seen during bronchoscopy, which can be similar to findings of tracheobronchiopathia osteoplastica. Prognosis is variable, as individuals may have stable lung function for years or develop extensive airway compromise resulting in death from respiratory failure, including pulmonary hemorrhage and pneumonia.