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Genetic Discovery, Rigorous Statistics, and Pandemic InfluenzaGenetic Discovery and Pandemic Influenza

Mary Beth Scholand, MD, FCCP; Theodore G. Liou, MD, FCCP
Author and Funding Information

From the Department of Internal Medicine, Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, School of Medicine, University of Utah.

Correspondence to: Theodore G. Liou, MD, FCCP, Department of Internal Medicine, Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, School of Medicine, University of Utah, 26 NMario Capecchi Dr, Salt Lake City, UT 84132; e-mail: ted.liou@utah.edu


Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Dr Scholand is a member of the American College of Chest Physicians Interstitial Lung Disease Steering Committee. She receives funding from the National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) and the University of Utah Genome Project. She is a site principal investigator for clinical trials and in this capacity receives funding from InterMune; Gilead Sciences, Inc; Boehringer-Ingelheim GmbH; Roche; MedImmune; FibroGen, Inc; and Bristol-Meyers Squibb. Dr Liou is a member of the Editorial Board of CHEST and an ad hoc member of the Clinical Research Study Review Committee of the US Cystic Fibrosis Foundation (CFF); he is a recent past member of the Thoracic Committee of the United Network for Organ Sharing/Organization for the Procurement and Transplantation Network, the CFF Patient Registry Data Use Committee, the REVEAL Steering Committee (sponsored by Actelion Pharmaceuticals Ltd), and the National Institute for Occupational Safety and Health World Trade Center Research Review Committee. He has received grant funding from CFF Therapeutics, Inc; the NIH/NHLBI; and the Margolis Family Foundation of Utah; and receives funding for studies of therapies from CFF Therapeutics, Inc; Genentech Inc; Gilead Sciences, Inc; Inspire; MPex Pharmaceuticals, Inc; Savara Pharmaceuticals; and Vertex. He is a consultant for Gehrson Lehman Group, Inc; Genentech Inc; and Vertex.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;145(6):1186-1188. doi:10.1378/chest.14-0137
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Pandemic influenza threatens public health globally.1 The pandemic 2009 influenza A(H1N1) (A[H1N1]pdm09) caused serious morbidity and high case-fatality rates worldwide: 214 countries reported 18,837 deaths during the first 6 months of 2010.2 Patients with chronic medical conditions were especially prone to poor outcomes,3-5 but this strain of influenza, similar to the 1918 “Spanish” influenza virus in both genetic sequence6 and behavior,7 caused unusually severe effects in young adults. A(H1N1)pdm09 has the additional distinction of producing poor outcomes among pregnant3,4 and obese patients,8 a phenomenon not seen with other recent strains of influenza.

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