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Sex Differences in Response to Pulmonary Arterial Hypertension TherapySex Differences in the Right Ventricle: Is What’s Good for the Goose, Good for the Gander?

Nathan Hatton, MD; John J. Ryan, MD
Author and Funding Information

From the Division of Pulmonary Medicine (Dr Hatton) and Division of Cardiovascular Medicine (Dr Ryan), Department of Medicine, the University of Utah.

Correspondence to: John J. Ryan, MD, Division of Cardiovascular Medicine, University of Utah Health Science Center, 30 N 1900 E, Room 4A100, Salt Lake City, UT 84132; e-mail: john.ryan@hsc.utah.edu


Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians. See online for more details.


Chest. 2014;145(6):1184-1186. doi:10.1378/chest.13-3061
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Extract

Pulmonary arterial hypertension (PAH) is predominantly a disease of women, with ratios of 4:1 in the Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL Registry),1 2:1 in the UK and Ireland registry,2 and 2:1 in the French registry also.3 However, the prognosis is worse in men with PAH compared with female patients,4 with the 5-year survival from diagnosis of PAH being estimated at 62% in women compared with 52% in men.5 The reason for this discrepancy in survival has been poorly understood and understudied.

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